VEGFB (vascular endothelial growth factor B)

2003-02-01  

Identity

HGNC
LOCATION
11q13.1
LOCUSID
ALIAS
VEGFL,VRF
FUSION GENES

Other Information

Locus ID:

NCBI: 7423
MIM: 601398
HGNC: 12681
Ensembl: ENSG00000173511

Variants:

dbSNP: 7423
ClinVar: 7423
TCGA: ENSG00000173511
COSMIC: VEGFB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173511ENST00000309422P49765
ENSG00000173511ENST00000309422Q7LAP4
ENSG00000173511ENST00000426086P49765
ENSG00000173511ENST00000541681H0YGB6

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Focal adhesionKEGGko04510
Cytokine-cytokine receptor interactionKEGGhsa04060
Focal adhesionKEGGhsa04510
Pathways in cancerKEGGhsa05200
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGF ligand-receptor interactionsREACTOMER-HSA-194313
VEGF binds to VEGFR leading to receptor dimerizationREACTOMER-HSA-195399
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA130232992bevacizumabChemicalPathwayassociated20124951
PA166118342afliberceptChemicalPathwayassociated20124951
PA28180FLT1GenePathwayassociated20124951
PA30086KDRGenePathwayassociated20124951
PA31783NRP1GenePathwayassociated20124951

References

Pubmed IDYearTitleCitations
126522952003A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2.180
221727222011WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing.88
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
236973672013A microRNA signature defines chemoresistance in ovarian cancer through modulation of angiogenesis.66
216368032011Overexpression of VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, leads to insufficient angiogenesis in patients with systemic sclerosis.51
187578272008Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy.42
185116992008Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium.37
206738682010A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).36
249870052014Vascular endothelial growth factor-B in physiology and disease.35
204524822010Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.26

Citation

Dessen P

VEGFB (vascular endothelial growth factor B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42788/vegfb-(vascular-endothelial-growth-factor-b)