VEGFB (vascular endothelial growth factor B)

2003-02-01  

Identity

HGNC
VEGFB
LOCATION
11q13.1
LOCUSID
7423
ALIAS
VEGFL,VRF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7423
MIM: 601398
HGNC: 12681
Ensembl: ENSG00000173511

Variants:

dbSNP: 7423
ClinVar: 7423
TCGA: ENSG00000173511
COSMIC: VEGFB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173511ENST00000309422P49765
ENSG00000173511ENST00000309422Q7LAP4
ENSG00000173511ENST00000426086P49765
ENSG00000173511ENST00000541681H0YGB6

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Focal adhesionKEGGko04510
Cytokine-cytokine receptor interactionKEGGhsa04060
Focal adhesionKEGGhsa04510
Pathways in cancerKEGGhsa05200
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGF ligand-receptor interactionsREACTOMER-HSA-194313
VEGF binds to VEGFR leading to receptor dimerizationREACTOMER-HSA-195399
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA130232992bevacizumabChemicalPathwayassociated20124951
PA166118342afliberceptChemicalPathwayassociated20124951
PA28180FLT1GenePathwayassociated20124951
PA30086KDRGenePathwayassociated20124951
PA31783NRP1GenePathwayassociated20124951

References

Pubmed IDYearTitleCitations
385366592024Sorcin promotes proliferation of hepatocellular carcinoma by regulating VEGFA/B via PI3K pathway.1
387750312024Chondroitin polymerizing factor promotes development and progression of colorectal cancer via facilitating transcription of VEGFB.1
385366592024Sorcin promotes proliferation of hepatocellular carcinoma by regulating VEGFA/B via PI3K pathway.1
387750312024Chondroitin polymerizing factor promotes development and progression of colorectal cancer via facilitating transcription of VEGFB.1
375918432023VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway.6
375918432023VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway.6
346474072022Peptides Derived from Vascular Endothelial Growth Factor B Show Potent Binding to Neuropilin-1.2
353999432022Increased Serum VEGF-B Level Is Associated With Renal Function Impairment in Patients With Type 2 Diabetes.3
346474072022Peptides Derived from Vascular Endothelial Growth Factor B Show Potent Binding to Neuropilin-1.2
353999432022Increased Serum VEGF-B Level Is Associated With Renal Function Impairment in Patients With Type 2 Diabetes.3
338562622021Co-expression of VEGF-B and FLT-1 correlates with malignancy and prognosis of gastric cancer.2
343018212021The Aryl Hydrocarbon Receptor-Dependent TGF-α/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis.7
338562622021Co-expression of VEGF-B and FLT-1 correlates with malignancy and prognosis of gastric cancer.2
343018212021The Aryl Hydrocarbon Receptor-Dependent TGF-α/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis.7
324995052020Molecular docking, synthesis and biological evaluation of Vascular Endothelial Growth Factor (VEGF) B based peptide as antiangiogenic agent targeting the second domain of the Vascular Endothelial Growth Factor Receptor 1 (VEGFR1D2) for anticancer application.10

Citation

Dessen P

VEGFB (vascular endothelial growth factor B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42788/vegfb-(vascular-endothelial-growth-factor-b)