VIPR1 (vasoactive intestinal peptide receptor 1)

2003-11-01  

Identity

HGNC
LOCATION
3p22.1
LOCUSID
ALIAS
HVR1,II,PACAP-R-2,PACAP-R2,RDC1,V1RG,VAPC1,VIP-R-1,VIPR,VIRG,VPAC1,VPAC1R,VPCAP1R
FUSION GENES

Other Information

Locus ID:

NCBI: 7433
MIM: 192321
HGNC: 12694
Ensembl: ENSG00000114812

Variants:

dbSNP: 7433
ClinVar: 7433
TCGA: ENSG00000114812
COSMIC: VIPR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114812ENST00000325123P32241
ENSG00000114812ENST00000433647P32241
ENSG00000114812ENST00000433647A0A024R2N2
ENSG00000114812ENST00000436487F2Z2U6
ENSG00000114812ENST00000438259P32241
ENSG00000114812ENST00000439731C9JDT8
ENSG00000114812ENST00000439910F2Z2U6
ENSG00000114812ENST00000443646F2Z2U6
ENSG00000114812ENST00000446673F2Z2U6
ENSG00000114812ENST00000450274C9JH33
ENSG00000114812ENST00000543411P32241

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
358649522022Activation of VIPR1 suppresses hepatocellular carcinoma progression by regulating arginine and pyrimidine metabolism.6
358697572022[VIPR1 promoter methylation promotes transcription factor AP-2α binding to inhibit VIPR1 expression and promote hepatocellular carcinoma cell growth in vitro].0
364302752022PAC(1), VPAC(1), and VPAC(2) Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.1
358649522022Activation of VIPR1 suppresses hepatocellular carcinoma progression by regulating arginine and pyrimidine metabolism.6
358697572022[VIPR1 promoter methylation promotes transcription factor AP-2α binding to inhibit VIPR1 expression and promote hepatocellular carcinoma cell growth in vitro].0
364302752022PAC(1), VPAC(1), and VPAC(2) Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.1
328077822020Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy.93
328077822020Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy.93
304077032019Upregulation of intestinal mucosal mast cells expressing VPAC1 in close proximity to vasoactive intestinal polypeptide in inflammatory bowel disease and murine colitis.17
305838642019Promoter methylation and H3K27 deacetylation regulate the transcription of VIPR1 in hepatocellular carcinoma.11
306926372019VPAC1 couples with TRPV4 channel to promote calcium-dependent gastric cancer progression via a novel autocrine mechanism.27
3081084920193D structure prediction of VAPC1 and identification of dual natural inhibitors for VPAC1 and EGFR.2
310891612019Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients.11
314085342019Immune evasion by Salmonella: exploiting the VPAC1/VIP axis in human monocytes.0
315600892019Mechanism of VIPR1 gene regulating human lung adenocarcinoma H1299 cells.16

Citation

Dessen P

VIPR1 (vasoactive intestinal peptide receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42792/vipr1-(vasoactive-intestinal-peptide-receptor-1)