VPREB1 (V-set pre-B cell surrogate light chain 1)

2003-05-01 Affiliation

Identity

HGNC

VPREB1

LOCATION

22q11.22

LOCUSID

7441

ALIAS

CD179a,IGI,IGVPB,VPREB

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7441
MIM: 605141
HGNC: 12709
Ensembl: ENSG00000169575
IMGT/GENE-DB:

Variants:

dbSNP: 7441
ClinVar: 7441
TCGA: ENSG00000169575
COSMIC: VPREB1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000169575	ENST00000302273	F8W8C9
ENSG00000169575	ENST00000403807	P12018

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Hemostasis	REACTOME	R-HSA-109582
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35398858	2022	Mutational Analysis of the VPREB1 Gene of Pre-BCR Complex in a Cohort of Sporadic Pediatric Patients With B-Cell Acute Lymphoblastic Leukemia.	0
35398858	2022	Mutational Analysis of the VPREB1 Gene of Pre-BCR Complex in a Cohort of Sporadic Pediatric Patients With B-Cell Acute Lymphoblastic Leukemia.	0
33418558	2021	CRISPR/Cas9 mediated knock-out of VPREB1 gene induces a cytotoxic effect in myeloma cells.	4
33418558	2021	CRISPR/Cas9 mediated knock-out of VPREB1 gene induces a cytotoxic effect in myeloma cells.	4
33101545	2020	Association of VPREB1 Gene Copy Number Variation and Rheumatoid Arthritis Susceptibility.	2
33101545	2020	Association of VPREB1 Gene Copy Number Variation and Rheumatoid Arthritis Susceptibility.	2
27611867	2016	The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia.	18
27611867	2016	The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia.	18
23881307	2014	VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia.	13
23881307	2014	VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia.	13
21144590	2011	The potential role of VPREB1 gene copy number variation in susceptibility to rheumatoid arthritis.	6
21144590	2011	The potential role of VPREB1 gene copy number variation in susceptibility to rheumatoid arthritis.	6
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	37
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	37
16818733	2006	Clustering of pre-B cell integrins induces galectin-1-dependent pre-B cell receptor relocalization and activation.	32

Citation

Dessen P

VPREB1 (V-set pre-B cell surrogate light chain 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42794