WASF3 (WASP family member 3)

2003-02-01  

Identity

HGNC
WASF3
LOCATION
13q12.13
LOCUSID
10810
ALIAS
Brush-1,SCAR3,WAVE3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10810
MIM: 605068
HGNC: 12734
Ensembl: ENSG00000132970

Variants:

dbSNP: 10810
ClinVar: 10810
TCGA: ENSG00000132970
COSMIC: WASF3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132970ENST00000335327Q9UPY6
ENSG00000132970ENST00000335327Q5T8P4
ENSG00000132970ENST00000361042Q9UPY6
ENSG00000132970ENST00000671038A0A590UJ74

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Adherens junctionKEGGko04520
Adherens junctionKEGGhsa04520
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379479482024WAVE3 Facilitates the Tumorigenesis and Metastasis of Tongue Squamous Cell Carcinoma via EMT.0
379479482024WAVE3 Facilitates the Tumorigenesis and Metastasis of Tongue Squamous Cell Carcinoma via EMT.0
369494682023The WAVE3/β-catenin oncogenic signaling regulates chemoresistance in triple negative breast cancer.2
369494682023The WAVE3/β-catenin oncogenic signaling regulates chemoresistance in triple negative breast cancer.2
356915392022Targeting the WASF3 complex to suppress metastasis.10
356915392022Targeting the WASF3 complex to suppress metastasis.10
334676812021Targeting WASF3 Signaling in Metastatic Cancer.12
335941552021Phosphorylation of the proline-rich domain of WAVE3 drives its oncogenic activity in breast cancer.5
344653612021SHOX2 cooperates with STAT3 to promote breast cancer metastasis through the transcriptional activation of WASF3.12
334676812021Targeting WASF3 Signaling in Metastatic Cancer.12
335941552021Phosphorylation of the proline-rich domain of WAVE3 drives its oncogenic activity in breast cancer.5
344653612021SHOX2 cooperates with STAT3 to promote breast cancer metastasis through the transcriptional activation of WASF3.12
321046802020Asiatic Acid Interferes with Invasion and Proliferation of Breast Cancer Cells by Inhibiting WAVE3 Activation through PI3K/AKT Signaling Pathway.15
323077652020MicroRNA-93 targets WASF3 and functions as a metastasis suppressor in breast cancer.17
323595342020WASF3 Knockdown Sensitizes Gastric Cancer Cells to Oxaliplatin by Inhibiting ATG12-Mediated Autophagy.6

Citation

Dessen P

WASF3 (WASP family member 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42802/wasf3-(wasp-family-member-3)