WASF3 (WASP family member 3)

2003-02-01  

Identity

HGNC
LOCATION
13q12.13
LOCUSID
ALIAS
Brush-1,SCAR3,WAVE3
FUSION GENES

Other Information

Locus ID:

NCBI: 10810
MIM: 605068
HGNC: 12734
Ensembl: ENSG00000132970

Variants:

dbSNP: 10810
ClinVar: 10810
TCGA: ENSG00000132970
COSMIC: WASF3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132970ENST00000335327Q9UPY6
ENSG00000132970ENST00000335327Q5T8P4
ENSG00000132970ENST00000361042Q9UPY6
ENSG00000132970ENST00000671038A0A590UJ74

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Adherens junctionKEGGko04520
Adherens junctionKEGGhsa04520
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198016812009The miR200 family of microRNAs regulates WAVE3-dependent cancer cell invasion.56
159078372005WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression.52
158269412005WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinase.51
211050302011WAVE3, an actin remodeling protein, is regulated by the metastasis suppressor microRNA, miR-31, during the invasion-metastasis cascade.49
176236722007c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration.48
223152302012HSP90 and HSP70 proteins are essential for stabilization and activation of WASF3 metastasis-promoting protein.35
233184382014WASF3 regulates miR-200 inactivation by ZEB1 through suppression of KISS1 leading to increased invasiveness in breast cancer cells.34
215448012011Functional interrelationship between the WASF3 and KISS1 metastasis-associated genes in breast cancer cells.28
157524302005Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2.27
121856002002WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma.25

Citation

Dessen P

WASF3 (WASP family member 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42802/wasf3-(wasp-family-member-3)