WASL (WASP like actin nucleation promoting factor)

2003-11-01  

Identity

HGNC
LOCATION
7q31.32
LOCUSID
ALIAS
N-WASP,NWASP,WASPB
FUSION GENES

Other Information

Locus ID:

NCBI: 8976
MIM: 605056
HGNC: 12735
Ensembl: ENSG00000106299

Variants:

dbSNP: 8976
ClinVar: 8976
TCGA: ENSG00000106299
COSMIC: WASL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106299ENST00000223023O00401

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Adherens junctionKEGGko04520
Tight junctionKEGGko04530
Regulation of actin cytoskeletonKEGGko04810
Pathogenic Escherichia coli infectionKEGGko05130
Adherens junctionKEGGhsa04520
Tight junctionKEGGhsa04530
Regulation of actin cytoskeletonKEGGhsa04810
Pathogenic Escherichia coli infectionKEGGhsa05130
ShigellosisKEGGhsa05131
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Bacterial invasion of epithelial cellsKEGGko05100
Bacterial invasion of epithelial cellsKEGGhsa05100
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
MetabolismREACTOMER-HSA-1430728
Metabolism of nitric oxideREACTOMER-HSA-202131
eNOS activation and regulationREACTOMER-HSA-203765
NOSTRIN mediated eNOS traffickingREACTOMER-HSA-203641
Cell-Cell communicationREACTOMER-HSA-1500931
Nephrin interactionsREACTOMER-HSA-373753
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752
DCC mediated attractive signalingREACTOMER-HSA-418885
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHB-mediated forward signalingREACTOMER-HSA-3928662
Clathrin-mediated endocytosisREACTOMER-HSA-8856828

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
152609902004Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex.155
151698912004Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP.106
184307342008N-wasp and the arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses.92
192626732009The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility.71
170854362007IQGAP1 stimulates actin assembly through the N-WASP-Arp2/3 pathway.68
167670802006Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners.65
166873952006The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity.47
217854202011N-WASP regulates the epithelial junctional actin cytoskeleton through a non-canonical post-nucleation pathway.47
208809862010Estrogen receptor-alpha promotes breast cancer cell motility and invasion via focal adhesion kinase and N-WASP.45
162936142006Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP.43

Citation

Dessen P

WASL (WASP like actin nucleation promoting factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42803/wasl-(wasp-like-actin-nucleation-promoting-factor)