WEE1 (WEE1 G2 checkpoint kinase)

2003-05-01  

Identity

HGNC
WEE1
LOCATION
11p15.4
LOCUSID
7465
ALIAS
WEE1A,WEE1hu
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7465
MIM: 193525
HGNC: 12761
Ensembl: ENSG00000166483

Variants:

dbSNP: 7465
ClinVar: 7465
TCGA: ENSG00000166483
COSMIC: WEE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166483ENST00000299613P30291
ENSG00000166483ENST00000450114P30291
ENSG00000166483ENST00000524612E9PQ51
ENSG00000166483ENST00000527848E9PRI3
ENSG00000166483ENST00000530175H0YEJ2
ENSG00000166483ENST00000530712E9PRU3

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Cell cycle - G2/M transitionKEGGhsa_M00693
Cell cycle - G2/M transitionKEGGM00693
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexREACTOMER-HSA-75035
G2/M DNA replication checkpointREACTOMER-HSA-69478
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
Cyclin E associated events during G1/S transitionREACTOMER-HSA-69202
S PhaseREACTOMER-HSA-69242
Cyclin A:Cdk2-associated events at S phase entryREACTOMER-HSA-69656
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Cyclin A/B1 associated events during G2/M transitionREACTOMER-HSA-69273
Polo-like kinase mediated eventsREACTOMER-HSA-156711

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375165912024Circulating RNA ZFR promotes hepatocellular carcinoma cell proliferation and epithelial-mesenchymal transition process through miR-624-3p/WEE1 axis.2
380474732024In silico and structure-based evaluation of deleterious mutations identified in human Chk1, Chk2, and Wee1 protein kinase.0
375165912024Circulating RNA ZFR promotes hepatocellular carcinoma cell proliferation and epithelial-mesenchymal transition process through miR-624-3p/WEE1 axis.2
380474732024In silico and structure-based evaluation of deleterious mutations identified in human Chk1, Chk2, and Wee1 protein kinase.0
363785282023ODF2L acts as a synthetic lethal partner with WEE1 inhibition in epithelial ovarian cancer models.1
378633242023E2F8 exerts cancer-promoting effects by transcriptionally activating RRM2 and E2F8 knockdown synergizes with WEE1 inhibition in suppressing lung adenocarcinoma.1
363785282023ODF2L acts as a synthetic lethal partner with WEE1 inhibition in epithelial ovarian cancer models.1
378633242023E2F8 exerts cancer-promoting effects by transcriptionally activating RRM2 and E2F8 knockdown synergizes with WEE1 inhibition in suppressing lung adenocarcinoma.1
346647762022Circ-SNAP47 (hsa_circ_0016760) and miR-625-5p are regulators of WEE1 in regulation of chemoresistance, growth and invasion of DDP-tolerant NSCLC cells via ceRNA pathway.4
350452932022WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity.22
350800312022Verbascoside enhances radiosensitivity of hepatocellular carcinoma cells through regulating miR-101-3p/Wee1 axis.2
351273432022miR-138-5p Inhibits the Growth and Invasion of Glioma Cells by Regulating WEE1.3
351761682022Inhibiting WEE1 and IKK-RELA Crosstalk Overcomes TNFα Resistance in Head and Neck Cancers.5
353153552022WEE1 kinase is a therapeutic vulnerability in CIC-DUX4 undifferentiated sarcoma.4
361657272022Mitotic Checkpoints and the Role of WEE1 Inhibition in Head and Neck Squamous Cell Carcinoma.2

Citation

Dessen P

WEE1 (WEE1 G2 checkpoint kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42807/wee1-(wee1-g2-checkpoint-kinase)