WNT2 (Wnt family member 2)

2003-02-01  

Identity

HGNC
WNT2
LOCATION
7q31.2
LOCUSID
7472
ALIAS
INT1L1,IRP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7472
MIM: 147870
HGNC: 12780
Ensembl: ENSG00000105989

Variants:

dbSNP: 7472
ClinVar: 7472
TCGA: ENSG00000105989
COSMIC: WNT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105989ENST00000265441P09544
ENSG00000105989ENST00000265441A0A384MDX3
ENSG00000105989ENST00000449446F8WDR1
ENSG00000105989ENST00000491214C9JUI2
ENSG00000105989ENST00000647844A0A3B3ITC9

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
Wnt signaling pathwayKEGGko04310
MelanogenesisKEGGko04916
Basal cell carcinomaKEGGko05217
mTOR signaling pathwayKEGGhsa04150
Wnt signaling pathwayKEGGhsa04310
MelanogenesisKEGGhsa04916
Pathways in cancerKEGGhsa05200
Basal cell carcinomaKEGGhsa05217
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Wnt signalingKEGGhsa_M00677
Wnt signalingKEGGM00677
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Signaling by WntREACTOMER-HSA-195721
WNT ligand biogenesis and traffickingREACTOMER-HSA-3238698
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

References

Pubmed IDYearTitleCitations
350376952022Overexpression of IL-8 and Wnt2 is associated with prognosis of gastric cancer.3
350376952022Overexpression of IL-8 and Wnt2 is associated with prognosis of gastric cancer.3
342749702021WNT2 activation through proximal germline deletion predisposes to small intestinal neuroendocrine tumors and intestinal adenocarcinomas.5
343753062021LncRNA-HAGLR motivates triple negative breast cancer progression by regulation of WNT2 via sponging miR-335-3p.8
344772432021Distinguishing colorectal adenoma from hyperplastic polyp by WNT2 expression.10
346665602021Prognostic Significance of Wnt1, Wnt2, E-Cadherin, and β-catenin Expression in Operable Non-small Cell Lung Cancer.0
348623052021A translational exploration of the effects of WNT2 variants on altered cortical structures in autism spectrum disorder.1
342749702021WNT2 activation through proximal germline deletion predisposes to small intestinal neuroendocrine tumors and intestinal adenocarcinomas.5
343753062021LncRNA-HAGLR motivates triple negative breast cancer progression by regulation of WNT2 via sponging miR-335-3p.8
344772432021Distinguishing colorectal adenoma from hyperplastic polyp by WNT2 expression.10
346665602021Prognostic Significance of Wnt1, Wnt2, E-Cadherin, and β-catenin Expression in Operable Non-small Cell Lung Cancer.0
348623052021A translational exploration of the effects of WNT2 variants on altered cortical structures in autism spectrum disorder.1
327795462020Involvement of WNT2 in trophoblast cell behavior in preeclampsia development.2
331552092020MiR-548b suppresses proliferative capacity of colorectal cancer by binding WNT2.7
327795462020Involvement of WNT2 in trophoblast cell behavior in preeclampsia development.2

Citation

Dessen P

WNT2 (Wnt family member 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42820/wnt2-(wnt-family-member-2)