WNT5B (Wnt family member 5B)

2003-02-01  

Identity

HGNC
LOCATION
12p13.33
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 81029
MIM: 606361
HGNC: 16265
Ensembl: ENSG00000111186

Variants:

dbSNP: 81029
ClinVar: 81029
TCGA: ENSG00000111186
COSMIC: WNT5B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111186ENST00000310594Q9H1J7
ENSG00000111186ENST00000397196Q9H1J7
ENSG00000111186ENST00000537031Q9H1J7
ENSG00000111186ENST00000539198F5H034
ENSG00000111186ENST00000542408F5GYM2
ENSG00000111186ENST00000543071F5H7Q6
ENSG00000111186ENST00000545811F5H364

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
Wnt signaling pathwayKEGGko04310
Axon guidanceKEGGko04360
MelanogenesisKEGGko04916
Basal cell carcinomaKEGGko05217
mTOR signaling pathwayKEGGhsa04150
Wnt signaling pathwayKEGGhsa04310
Axon guidanceKEGGhsa04360
MelanogenesisKEGGhsa04916
Pathways in cancerKEGGhsa05200
Basal cell carcinomaKEGGhsa05217
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Wnt signalingKEGGhsa_M00677
Wnt signalingKEGGM00677
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
WNT ligand biogenesis and traffickingREACTOMER-HSA-3238698
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
PCP/CE pathwayREACTOMER-HSA-4086400
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD23817222
PA164713176Platinum compoundsChemicalClinicalAnnotationassociatedPD24980784
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD24980784
PA443756Colonic NeoplasmsDiseaseClinicalAnnotationassociatedPD23817222

References

Pubmed IDYearTitleCitations
379718822024DLL4/Notch3/WNT5B axis mediates bidirectional prometastatic crosstalk between melanoma and lymphatic endothelial cells.0
385316602024Role of Wnt5b-Ror1 signaling in the proliferation of pancreatic ductal adenocarcinoma cells.0
386894292024WNT5B drives osteosarcoma stemness, chemoresistance and metastasis.2
379718822024DLL4/Notch3/WNT5B axis mediates bidirectional prometastatic crosstalk between melanoma and lymphatic endothelial cells.0
385316602024Role of Wnt5b-Ror1 signaling in the proliferation of pancreatic ductal adenocarcinoma cells.0
386894292024WNT5B drives osteosarcoma stemness, chemoresistance and metastasis.2
349063302022Estrogen receptor alpha and NFATc1 bind to a bone mineral density-associated SNP to repress WNT5B in osteoblasts.8
349063302022Estrogen receptor alpha and NFATc1 bind to a bone mineral density-associated SNP to repress WNT5B in osteoblasts.8
345365742021Exosome-mediated circ_0001846 participates in IL-1β-induced chondrocyte cell damage by miR-149-5p-dependent regulation of WNT5B.14
345365742021Exosome-mediated circ_0001846 participates in IL-1β-induced chondrocyte cell damage by miR-149-5p-dependent regulation of WNT5B.14
316666822020WNT5B exerts oncogenic effects and is negatively regulated by miR-5587-3p in lung adenocarcinoma progression.18
320923302020Up-regulated miR-374a-3p relieves lipopolysaccharides induced injury in CHON-001 cells via regulating Wingless-type MMTV integration site family member 5B.8
325617392020The lncRNA RP11-142A22.4 promotes adipogenesis by sponging miR-587 to modulate Wnt5β expression.16
316666822020WNT5B exerts oncogenic effects and is negatively regulated by miR-5587-3p in lung adenocarcinoma progression.18
320923302020Up-regulated miR-374a-3p relieves lipopolysaccharides induced injury in CHON-001 cells via regulating Wingless-type MMTV integration site family member 5B.8

Citation

Dessen P

WNT5B (Wnt family member 5B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42826/wnt5b-(wnt-family-member-5b)