WTAP (WT1 associated protein)

2003-02-01  

Identity

HGNC
WTAP
LOCATION
6q25.3
LOCUSID
9589
ALIAS
Mum2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9589
MIM: 605442
HGNC: 16846
Ensembl: ENSG00000146457

Variants:

dbSNP: 9589
ClinVar: 9589
TCGA: ENSG00000146457
COSMIC: WTAP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146457ENST00000337387Q15007
ENSG00000146457ENST00000358372Q15007
ENSG00000146457ENST00000614346A0A087X1R4
ENSG00000146457ENST00000621533Q15007
ENSG00000146457ENST00000631126A0A087X1R4
ENSG00000146457ENST00000650096Q15007

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
244074212014Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase.348
241000412013Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle.75
244133222014WTAP is a novel oncogenic protein in acute myeloid leukemia.46
170885322006Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA.35
314389612019WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1.24
199693842010Evaluation of podocyte lesion in patients with diabetic nephropathy: Wilms' tumor-1 protein used as a podocyte marker.22
229579192012Expression and roles of Wilms' tumor 1-associating protein in glioblastoma.22
233546232013WTAP regulates migration and invasion of cholangiocarcinoma cells.19
169121812006Wilms' tumor 1 and signal transducers and activators of transcription 3 synergistically promote cell proliferation: a possible mechanism in sporadic Wilms' tumor.17
273705402016WTAP Expression Predicts Poor Prognosis in Malignant Glioma Patients.15

Citation

Dessen P

WTAP (WT1 associated protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42838/wtap-(wt1-associated-protein)