ZBTB17 (zinc finger and BTB domain containing 17)

2003-02-01  

Identity

HGNC
LOCATION
1p36.13
LOCUSID
ALIAS
MIZ-1,ZNF151,ZNF60,pHZ-67
FUSION GENES

Other Information

Locus ID:

NCBI: 7709
MIM: 604084
HGNC: 12936
Ensembl: ENSG00000116809

Variants:

dbSNP: 7709
ClinVar: 7709
TCGA: ENSG00000116809
COSMIC: ZBTB17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116809ENST00000375733Q13105
ENSG00000116809ENST00000375743Q13105
ENSG00000116809ENST00000440560H7C1K8
ENSG00000116809ENST00000444358H0Y6X2
ENSG00000116809ENST00000537142Q13105

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
365389832023Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10.5
370408442023A TNFα/Miz1-positive feedback loop inhibits mitophagy in hepatocytes and propagates non-alcoholic steatohepatitis.9
365389832023Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10.5
370408442023A TNFα/Miz1-positive feedback loop inhibits mitophagy in hepatocytes and propagates non-alcoholic steatohepatitis.9
339143372021MXD/MIZ1 transcription regulatory complexes activate the expression of MYC-repressed genes.2
341450382021MYC- and MIZ1-Dependent Vesicular Transport of Double-Strand RNA Controls Immune Evasion in Pancreatic Ductal Adenocarcinoma.12
343058882021Identification of the SARS-CoV-2 Entry Receptor ACE2 as a Direct Target for Transcriptional Repression by Miz1.4
339143372021MXD/MIZ1 transcription regulatory complexes activate the expression of MYC-repressed genes.2
341450382021MYC- and MIZ1-Dependent Vesicular Transport of Double-Strand RNA Controls Immune Evasion in Pancreatic Ductal Adenocarcinoma.12
343058882021Identification of the SARS-CoV-2 Entry Receptor ACE2 as a Direct Target for Transcriptional Repression by Miz1.4
330573312020Identification of the transcription factor Miz1 as an essential regulator of diphthamide biosynthesis using a CRISPR-mediated genome-wide screen.2
330573312020Identification of the transcription factor Miz1 as an essential regulator of diphthamide biosynthesis using a CRISPR-mediated genome-wide screen.2
294459302018ZBTB17 loss-of-function mutation contributes to familial dilated cardiomyopathy.2
294459302018ZBTB17 loss-of-function mutation contributes to familial dilated cardiomyopathy.2
275278912017Miz1, a Novel Target of ING4, Can Drive Prostate Luminal Epithelial Cell Differentiation.3

Citation

Dessen P

ZBTB17 (zinc finger and BTB domain containing 17)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42872/zbtb17-(zinc-finger-and-btb-domain-containing-17)