ZW10 (zw10 kinetochore protein)

2003-11-01  

Identity

HGNC
LOCATION
11q23.2
LOCUSID
ALIAS
HZW10,KNTC1AP

Other Information

Locus ID:

NCBI: 9183
MIM: 603954
HGNC: 13194
Ensembl: ENSG00000086827

Variants:

dbSNP: 9183
ClinVar: 9183
TCGA: ENSG00000086827
COSMIC: ZW10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000086827ENST00000200135O43264
ENSG00000086827ENST00000535142O43264
ENSG00000086827ENST00000538209F5H3C1

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
258495062015Complex assembly, crystallization and preliminary X-ray crystallographic analysis of the human Rod-Zwilch-ZW10 (RZZ) complex.3
258495062015Complex assembly, crystallization and preliminary X-ray crystallographic analysis of the human Rod-Zwilch-ZW10 (RZZ) complex.3
213451722011hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain.10
213451722011hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain.10
193694182009Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport.56
193694182009Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport.56
182681002008Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint.42
187822272008N-terminal region of ZW10 serves not only as a determinant for localization but also as a link with dynein function.7
182681002008Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint.42
187822272008N-terminal region of ZW10 serves not only as a determinant for localization but also as a link with dynein function.7
175609392007Correlation of Golgi localization of ZW10 and centrosomal accumulation of dynactin.10
176800272007Kinetochore dynein generates a poleward pulling force to facilitate congression and full chromosome alignment.34
176995962007Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis.49
180652242007Aurora B kinase-dependent recruitment of hZW10 and hROD to tensionless kinetochores.37
175609392007Correlation of Golgi localization of ZW10 and centrosomal accumulation of dynactin.10

Citation

Dessen P

ZW10 (zw10 kinetochore protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42887/zw10-(zw10-kinetochore-protein)