USP25 (ubiquitin specific peptidase 25)

2003-02-01  

Identity

HGNC
LOCATION
21q21.1
LOCUSID
ALIAS
USP21
FUSION GENES

Other Information

Locus ID:

NCBI: 29761
MIM: 604736
HGNC: 12624
Ensembl: ENSG00000155313

Variants:

dbSNP: 29761
ClinVar: 29761
TCGA: ENSG00000155313
COSMIC: USP25

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155313ENST00000285679Q9UHP3
ENSG00000155313ENST00000285681Q9UHP3
ENSG00000155313ENST00000351097Q96B65
ENSG00000155313ENST00000400183Q9UHP3
ENSG00000155313ENST00000449491H7C1T8
ENSG00000155313ENST00000453553H7C253

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
385217872024Expression of USP25 associates with fibrosis, inflammation and metabolism changes in IgG4-related disease.0
385217872024Expression of USP25 associates with fibrosis, inflammation and metabolism changes in IgG4-related disease.0
369387362023Regulation of USP25 by SP1 Associates with Amyloidogenesis.0
370593122023USP25 inhibits renal fibrosis by regulating TGFβ-SMAD signaling pathway in Ang II-induced hypertensive mice.4
371712862023USP25 contributes to defective neurogenesis and cognitive impairments.0
374393862023USP25 promotes hepatocellular carcinoma progression by interacting with TRIM21 via the Wnt/β-catenin signaling pathway.0
376836302023Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection.2
369387362023Regulation of USP25 by SP1 Associates with Amyloidogenesis.0
370593122023USP25 inhibits renal fibrosis by regulating TGFβ-SMAD signaling pathway in Ang II-induced hypertensive mice.4
371712862023USP25 contributes to defective neurogenesis and cognitive impairments.0
374393862023USP25 promotes hepatocellular carcinoma progression by interacting with TRIM21 via the Wnt/β-catenin signaling pathway.0
376836302023Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection.2
354500282022Deubiquitination of TNKS1 Regulates Wnt/β-Catenin to Affect the Expression of USP25 to Promote the Progression of Glioma.3
361556102022USP25 UPREGULATION BOOSTS GSDMD -MEDIATED PYROPTOSIS OF ACINAR CELLS IN ACUTE PANCREATITIS.3
361778922022Downregulation of deubiquitinating enzyme USP25 promotes the development of allergic rhinitis by enhancing TSLP signaling in the nasal epithelium.1

Citation

Dessen P

USP25 (ubiquitin specific peptidase 25)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/429/usp25-(ubiquitin-specific-peptidase-25)