CLC (Charcot-Leyden crystal galectin)

2004-11-01  

Identity

HGNC
CLC
LOCATION
19q13.2
LOCUSID
1178
ALIAS
GAL10,Gal-10,LGALS10,LGALS10A,LPPL_HUMAN

Other Information

Locus ID:

NCBI: 1178
MIM: 153310
HGNC: 2014
Ensembl: ENSG00000105205

Variants:

dbSNP: 1178
ClinVar: 1178
TCGA: ENSG00000105205
COSMIC: CLC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105205ENST00000221804Q05315

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
369883502023Glutathione disrupts galectin-10 Charcot-Leyden crystal formation to possibly ameliorate eosinophil-based diseases such as asthma.1
371026432023Behçet syndrome: The disturbed balance between anti- (CLEC12A, CLC) and proinflammatory (IFI27) gene expressions.1
376405662023Eosinophil-derived galectin-10 upregulates matrix metalloproteinase expression in bullous pemphigoid blisters.0
369883502023Glutathione disrupts galectin-10 Charcot-Leyden crystal formation to possibly ameliorate eosinophil-based diseases such as asthma.1
371026432023Behçet syndrome: The disturbed balance between anti- (CLEC12A, CLC) and proinflammatory (IFI27) gene expressions.1
376405662023Eosinophil-derived galectin-10 upregulates matrix metalloproteinase expression in bullous pemphigoid blisters.0
346474852022Chronic rhinosinusitis with nasal polyposis (CRSwNP): the correlation between expression of Galectin-10 and Clinical-Cytological Grading (CCG).11
352749502022Crystalline State Determines the Potency of Galectin-10 Protein Assembly to Induce Inflammation.1
362915932022Galectin-10 as a Potential Biomarker for Eosinophilic Diseases.7
346474852022Chronic rhinosinusitis with nasal polyposis (CRSwNP): the correlation between expression of Galectin-10 and Clinical-Cytological Grading (CCG).11
352749502022Crystalline State Determines the Potency of Galectin-10 Protein Assembly to Induce Inflammation.1
362915932022Galectin-10 as a Potential Biomarker for Eosinophilic Diseases.7
333000832021Identification of galectin‑10 as a biomarker for periodontitis based on proteomic analysis of gingival crevicular fluid.2
333000832021Identification of galectin‑10 as a biomarker for periodontitis based on proteomic analysis of gingival crevicular fluid.2
321083692020Galectin-10, the protein that forms Charcot-Leyden crystals, is not stored in granules but resides in the peripheral cytoplasm of human eosinophils.19

Citation

Dessen P

CLC (Charcot-Leyden crystal galectin)

Atlas Genet Cytogenet Oncol Haematol. 2004-11-01

Online version: http://atlasgeneticsoncology.org/gene/42926/gene-explorer/css/welcome