Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 348654
MIM: 612449
HGNC: 26881
Ensembl: ENSG00000178295
Variants:
dbSNP: 348654
ClinVar: 348654
TCGA: ENSG00000178295
COSMIC: GEN1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37840312 | 2024 | Reverse Transcription-PCR-based Sanger Sequencing-confirmed Exon-skipping Effect of a Novel GEN1 Intronic Variant (c.1408+4A>G). | 0 |
| 38654324 | 2024 | GEN1 as a risk factor for human congenital anomalies of the kidney and urinary tract. | 0 |
| 37840312 | 2024 | Reverse Transcription-PCR-based Sanger Sequencing-confirmed Exon-skipping Effect of a Novel GEN1 Intronic Variant (c.1408+4A>G). | 0 |
| 38654324 | 2024 | GEN1 as a risk factor for human congenital anomalies of the kidney and urinary tract. | 0 |
| 36380731 | 2022 | NCAPH Stabilizes GEN1 in Chromatin to Resolve Ultra-Fine DNA Bridges and Maintain Chromosome Stability. | 4 |
| 36380731 | 2022 | NCAPH Stabilizes GEN1 in Chromatin to Resolve Ultra-Fine DNA Bridges and Maintain Chromosome Stability. | 4 |
| 30590761 | 2019 | Resolution of the Holliday junction recombination intermediate by human GEN1 at the single-molecule level. | 8 |
| 30590761 | 2019 | Resolution of the Holliday junction recombination intermediate by human GEN1 at the single-molecule level. | 8 |
| 27990631 | 2017 | Holliday junction-resolving enzymes-structures and mechanisms. | 14 |
| 28049850 | 2017 | Resolution of single and double Holliday junction recombination intermediates by GEN1. | 21 |
| 28290553 | 2017 | SLX4 Prevents GEN1-Dependent DSBs During DNA Replication Arrest Under Pathological Conditions in Human Cells. | 7 |
| 28369583 | 2017 | Substrate preference of Gen endonucleases highlights the importance of branched structures as DNA damage repair intermediates. | 9 |
| 27990631 | 2017 | Holliday junction-resolving enzymes-structures and mechanisms. | 14 |
| 28049850 | 2017 | Resolution of single and double Holliday junction recombination intermediates by GEN1. | 21 |
| 28290553 | 2017 | SLX4 Prevents GEN1-Dependent DSBs During DNA Replication Arrest Under Pathological Conditions in Human Cells. | 7 |
Citation
Dessen P
GEN1 (GEN1 Holliday junction 5 flap endonuclease)
Atlas Genet Cytogenet Oncol Haematol. 2004-11-01
Online version: http://atlasgeneticsoncology.org/gene/42931/gen1-(gen1-holliday-junction-5-flap-endonuclease)
