EPC1 (enhancer of polycomb homolog 1)

2006-08-01  

Identity

HGNC
EPC1
LOCATION
10p11.22
LOCUSID
80314
ALIAS
Epl1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80314
MIM: 610999
HGNC: 19876
Ensembl: ENSG00000120616

Variants:

dbSNP: 80314
ClinVar: 80314
TCGA: ENSG00000120616
COSMIC: EPC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120616ENST00000263062Q9H2F5
ENSG00000120616ENST00000319778Q9H2F5
ENSG00000120616ENST00000375110Q9H2F5
ENSG00000120616ENST00000469059A0A590UJ87
ENSG00000120616ENST00000480402A0A590UJ89
ENSG00000120616ENST00000667706A0A590UJN0

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847

References

Pubmed IDYearTitleCitations
361588852022Multiomics Integrative Analysis Identifying EPC1 as a Prognostic Biomarker in Head and Neck Squamous Cell Carcinoma.1
361588852022Multiomics Integrative Analysis Identifying EPC1 as a Prognostic Biomarker in Head and Neck Squamous Cell Carcinoma.1
322094632020Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex.8
322094632020Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex.8
263502152016Epigenetic factor EPC1 is a master regulator of DNA damage response by interacting with E2F1 to silence death and activate metastasis-related gene signatures.23
263502152016Epigenetic factor EPC1 is a master regulator of DNA damage response by interacting with E2F1 to silence death and activate metastasis-related gene signatures.23
257557232015RNA interference targeting enhancer of polycomb1 exerts anti-tumor effects in lung cancer.2
257557232015RNA interference targeting enhancer of polycomb1 exerts anti-tumor effects in lung cancer.2
241662972014Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells.24
241662972014Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells.24
189846742009KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise.11
194847612009Alteration of enhancer of polycomb 1 at 10p11.2 is one of the genetic events leading to development of adult T-cell leukemia/lymphoma.16
189846742009KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise.11
194847612009Alteration of enhancer of polycomb 1 at 10p11.2 is one of the genetic events leading to development of adult T-cell leukemia/lymphoma.16
171922672007Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation.32

Citation

Dessen P

EPC1 (enhancer of polycomb homolog 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-08-01

Online version: http://atlasgeneticsoncology.org/gene/42977/epc1-(enhancer-of-polycomb-homolog-1)