DCPS (decapping enzyme, scavenger)

2006-12-01  

Identity

HGNC
DCPS
LOCATION
11q24.2
LOCUSID
28960
ALIAS
ARS,DCS1,HINT-5,HINT5,HSL1,HSPC015
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 28960
MIM: 610534
HGNC: 29812
Ensembl: ENSG00000110063

Variants:

dbSNP: 28960
ClinVar: 28960
TCGA: ENSG00000110063
COSMIC: DCPS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110063ENST00000263579Q96C86
ENSG00000110063ENST00000263579A0A384MTI8
ENSG00000110063ENST00000648516A0A3B3ITF0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
mRNA decay by 3' to 5' exoribonucleaseREACTOMER-HSA-429958

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
121981722002The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases.98
150688042004Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity.45
145232402003DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway.31
184269212008DcpS scavenger decapping enzyme can modulate pre-mRNA splicing.14
257018702015Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment.14
157694642005Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping.12
184410142008Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme.10
257121292015Loss of the scavenger mRNA decapping enzyme DCPS causes syndromic intellectual disability with neuromuscular defects.10
260017962015DcpS is a transcript-specific modulator of RNA in mammalian cells.9
187252662009Proteomic approach to the identification of novel delta-lactoferrin target genes: Characterization of DcpS, an mRNA scavenger decapping enzyme.6

Citation

Dessen P

DCPS (decapping enzyme, scavenger)

Atlas Genet Cytogenet Oncol Haematol. 2006-12-01

Online version: http://atlasgeneticsoncology.org/gene/42988/dcps-(decapping-enzyme-scavenger)