MSRB3 (methionine sulfoxide reductase B3)

2005-02-01  

Identity

HGNC
MSRB3
LOCATION
12q14.3
LOCUSID
253827
ALIAS
DFNB74
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 253827
MIM: 613719
HGNC: 27375
Ensembl: ENSG00000174099

Variants:

dbSNP: 253827
ClinVar: 253827
TCGA: ENSG00000174099
COSMIC: MSRB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174099ENST00000308259Q8IXL7
ENSG00000174099ENST00000355192Q8IXL7
ENSG00000174099ENST00000446731H7C2B7
ENSG00000174099ENST00000535239F5H199
ENSG00000174099ENST00000535664Q8IXL7
ENSG00000174099ENST00000538045F5H7C4
ENSG00000174099ENST00000540804F5H6G9
ENSG00000174099ENST00000541189H0YFW5
ENSG00000174099ENST00000541897F5H4C9
ENSG00000174099ENST00000614640Q8IXL7
ENSG00000174099ENST00000642404Q8IXL7
ENSG00000174099ENST00000642411Q8IXL7
ENSG00000174099ENST00000646299Q8IXL7
ENSG00000174099ENST00000647481A0A2R8Y7J8

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein repairREACTOMER-HSA-5676934

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
318895862020MSRB3 promotes the progression of clear cell renal cell carcinoma via regulating endoplasmic reticulum stress.3
329086412020MicroRNA-874-3p Aggravates Doxorubicin-Induced Renal Podocyte Injury via Targeting Methionine Sulfoxide Reductase B3.3
318895862020MSRB3 promotes the progression of clear cell renal cell carcinoma via regulating endoplasmic reticulum stress.3
329086412020MicroRNA-874-3p Aggravates Doxorubicin-Induced Renal Podocyte Injury via Targeting Methionine Sulfoxide Reductase B3.3
307759932019Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in Alzheimer's Disease Associates with Increased Odds for Brain Infarcts.4
307759932019Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in Alzheimer's Disease Associates with Increased Odds for Brain Infarcts.4
294202542018Methionine sulfoxide reductase B3 requires resolving cysteine residues for full activity and can act as a stereospecific methionine oxidase.7
294202542018Methionine sulfoxide reductase B3 requires resolving cysteine residues for full activity and can act as a stereospecific methionine oxidase.7
280075932017Down-regulation of MsrB3 induces cancer cell apoptosis through reactive oxygen species production and intrinsic mitochondrial pathway activation.16
283892992017MsrB3 deficiency induces cancer cell apoptosis through p53-independent and ER stress-dependent pathways.13
283943292017A stemness-related ZEB1-MSRB3 axis governs cellular pliancy and breast cancer genome stability.78
287777542017Methionine Sulfoxide Reductase-B3 (MsrB3) Protein Associates with Synaptic Vesicles and its Expression Changes in the Hippocampi of Alzheimer's Disease Patients.11
280075932017Down-regulation of MsrB3 induces cancer cell apoptosis through reactive oxygen species production and intrinsic mitochondrial pathway activation.16
283892992017MsrB3 deficiency induces cancer cell apoptosis through p53-independent and ER stress-dependent pathways.13
283943292017A stemness-related ZEB1-MSRB3 axis governs cellular pliancy and breast cancer genome stability.78

Citation

Dessen P

MSRB3 (methionine sulfoxide reductase B3)

Atlas Genet Cytogenet Oncol Haematol. 2005-02-01

Online version: http://atlasgeneticsoncology.org/gene/43002/msrb3-(methionine-sulfoxide-reductase-b3)