Identity
HGNC
LOCATION
14q11.2
LOCUSID
ALIAS
ADPRT2,ADPRTL2,ADPRTL3,ARTD2,PARP-2,pADPRT-2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10038
MIM: 607725
HGNC: 272
Ensembl: ENSG00000129484
Variants:
dbSNP: 10038
ClinVar: 10038
TCGA: ENSG00000129484
COSMIC: PARP2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166163418 | rucaparib | Chemical | LabelAnnotation | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38029688 | 2024 | Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2. | 1 |
| 38029688 | 2024 | Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2. | 1 |
| 37216533 | 2023 | Single-molecule force spectroscopy reveals binding and bridging dynamics of PARP1 and PARP2 at DNA double-strand breaks. | 5 |
| 37326017 | 2023 | The CSB chromatin remodeler regulates PARP1- and PARP2-mediated single-strand break repair at actively transcribed DNA regions. | 3 |
| 37351597 | 2023 | PARP2 promotes inflammation in psoriasis by modulating estradiol biosynthesis in keratinocytes. | 1 |
| 37216533 | 2023 | Single-molecule force spectroscopy reveals binding and bridging dynamics of PARP1 and PARP2 at DNA double-strand breaks. | 5 |
| 37326017 | 2023 | The CSB chromatin remodeler regulates PARP1- and PARP2-mediated single-strand break repair at actively transcribed DNA regions. | 3 |
| 37351597 | 2023 | PARP2 promotes inflammation in psoriasis by modulating estradiol biosynthesis in keratinocytes. | 1 |
| 32785980 | 2021 | Progress and outlook in studying the substrate specificities of PARPs and related enzymes. | 33 |
| 33649352 | 2021 | The contribution of PARP1, PARP2 and poly(ADP-ribosyl)ation to base excision repair in the nucleosomal context. | 18 |
| 33925170 | 2021 | Functional Roles of PARP2 in Assembling Protein-Protein Complexes Involved in Base Excision DNA Repair. | 5 |
| 34051087 | 2021 | miRNA-149 targets PARP-2 in endometrial epithelial and stromal cells to regulate the trophoblast attachment process. | 4 |
| 34066057 | 2021 | PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling. | 27 |
| 34108479 | 2021 | Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition. | 21 |
| 34199944 | 2021 | Silencing of Poly(ADP-Ribose) Polymerase-2 Induces Mitochondrial Reactive Species Production and Mitochondrial Fragmentation. | 4 |
Citation
Dessen P
PARP2 (poly(ADP-ribose) polymerase 2)
Atlas Genet Cytogenet Oncol Haematol. 2005-11-01
Online version: http://atlasgeneticsoncology.org/gene/43063/
