XPO5 (exportin 5)

2005-11-01  

Identity

HGNC
XPO5
LOCATION
6p21.1
LOCUSID
57510
ALIAS
exp5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57510
MIM: 607845
HGNC: 17675
Ensembl: ENSG00000124571

Variants:

dbSNP: 57510
ClinVar: 57510
TCGA: ENSG00000124571
COSMIC: XPO5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124571ENST00000265351Q9HAV4
ENSG00000124571ENST00000398799E2QRM3
ENSG00000124571ENST00000398835H0Y3Q8
ENSG00000124571ENST00000455285H0Y3W3
ENSG00000124571ENST00000486936H0YA57
ENSG00000124571ENST00000496341H0Y9I3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Gene ExpressionREACTOMER-HSA-74160
Gene Silencing by RNAREACTOMER-HSA-211000
MicroRNA (miRNA) biogenesisREACTOMER-HSA-203927

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
373111192023Investigation of the association of the RAN (rs14035) and XPO5 (rs11077) polymorphisms with venous thromboembolism.0
376556232023Lipid kinase PIP5K1A regulates let-7 microRNA biogenesis through interacting with nuclear export protein XPO5.0
373111192023Investigation of the association of the RAN (rs14035) and XPO5 (rs11077) polymorphisms with venous thromboembolism.0
376556232023Lipid kinase PIP5K1A regulates let-7 microRNA biogenesis through interacting with nuclear export protein XPO5.0
343286432022Effects of Knockdown of XPO5 by siRNA on the Biological Behavior of Head and Neck Cancer Cells.1
348551932022The impact of Dicer, Drosha, and Exportin-5 levels in polycystic ovary syndrome (PCOS) diagnosis and phenotyping.0
363713112022Mutation in XPO5 causes adult-onset autosomal dominant familial focal segmental glomerulosclerosis.1
364755962022Amyotrophic Lateral Sclerosis-Associated Mutants of SOD1 Modulate miRNA Biogenesis through Aberrant Interactions with Exportin 5.2
343286432022Effects of Knockdown of XPO5 by siRNA on the Biological Behavior of Head and Neck Cancer Cells.1
348551932022The impact of Dicer, Drosha, and Exportin-5 levels in polycystic ovary syndrome (PCOS) diagnosis and phenotyping.0
363713112022Mutation in XPO5 causes adult-onset autosomal dominant familial focal segmental glomerulosclerosis.1
364755962022Amyotrophic Lateral Sclerosis-Associated Mutants of SOD1 Modulate miRNA Biogenesis through Aberrant Interactions with Exportin 5.2
345928962021Selectivity of Exportin 5 binding to human precursor microRNAs.6
345928962021Selectivity of Exportin 5 binding to human precursor microRNAs.6
312503752020Association between Genetic Polymorphisms in microRNA Machinery Genes and Risk of Papillary Thyroid Carcinoma.5

Citation

Dessen P

XPO5 (exportin 5)

Atlas Genet Cytogenet Oncol Haematol. 2005-11-01

Online version: http://atlasgeneticsoncology.org/gene/43077/xpo5-(exportin-5)