Identity
HGNC
LOCATION
17p11.2
LOCUSID
ALIAS
ABH5,OFOXD,OFOXD1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 54890
MIM: 613303
HGNC: 25996
Ensembl: ENSG00000091542
Variants:
dbSNP: 54890
ClinVar: 54890
TCGA: ENSG00000091542
COSMIC: ALKBH5
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000091542 | ENST00000399138 | Q6P6C2 |
| ENSG00000091542 | ENST00000541285 | K7ER58 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| DNA Repair | REACTOME | R-HSA-73894 |
| DNA Damage Reversal | REACTOME | R-HSA-73942 |
| Reversal of alkylation damage by DNA dioxygenases | REACTOME | R-HSA-73943 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37740102 | 2024 | Deficiency of N6-Methyladenosine Demethylase ALKBH5 Alleviates Ultraviolet B Radiation-Induced Chronic Actinic Dermatitis via Regulating Pyroptosis. | 0 |
| 37949419 | 2024 | ALKBH5 promotes the development of lung adenocarcinoma by regulating the polarization of M2 macrophages through CDCA4. | 1 |
| 38104484 | 2024 | M(6)A demethylase ALKBH5 regulates FOXO1 mRNA stability and chemoresistance in triple-negative breast cancer. | 1 |
| 38114747 | 2024 | The RNA m(6)A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression. | 1 |
| 38199493 | 2024 | ALKBH5 regulates paclitaxel resistance in NSCLC via inhibiting CEMIP-mediated EMT. | 1 |
| 38221546 | 2024 | ALKBH5 is a prognostic factor and promotes the angiogenesis of glioblastoma. | 0 |
| 38227578 | 2024 | The N6-methyladenosine demethylase ALKBH5 regulates the hypoxic HBV transcriptome. | 2 |
| 38252669 | 2024 | The promotive role of lncRNA MIR205HG in proliferation, invasion, and migration of melanoma cells via the JMJD2C/ALKBH5 axis. | 0 |
| 38273746 | 2024 | ALKBH5 Suppresses Autophagy in Prostate Cancer Cells via Inhibiting m6A-Modification of TSPAN1 mRNA. | 0 |
| 38331303 | 2024 | Hypoxia-induced ALKBH5 aggravates synovial aggression and inflammation in rheumatoid arthritis by regulating the m6A modification of CH25H. | 1 |
| 38481816 | 2024 | ALKBH5 facilitates the progression of skin cutaneous melanoma via mediating ABCA1 demethylation and modulating autophagy in an m(6)A-dependent manner. | 0 |
| 38568805 | 2024 | A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles. | 0 |
| 38637813 | 2024 | ALKBH5 modulates macrophages polarization in tumor microenvironment of ovarian cancer. | 0 |
| 38642004 | 2024 | High expression of AlkB homolog 5 suppresses the progression of non-small cell lung cancer by facilitating ferroptosis through m6A demethylation of SLC7A11. | 0 |
| 38745044 | 2024 | ALKBH5-mediated m6A modification of circFOXP1 promotes gastric cancer progression by regulating SOX4 expression and sponging miR-338-3p. | 0 |
Citation
Dessen P
ALKBH5 (alkB homolog 5, RNA demethylase)
Atlas Genet Cytogenet Oncol Haematol. 2006-05-01
Online version: http://atlasgeneticsoncology.org/gene/43079/alkbh5-(alkb-homolog-5-rna-demethylase)
