ZFPM2 (zinc finger protein, FOG family member 2)

2004-05-01  

Identity

HGNC
ZFPM2
LOCATION
8q23.1
LOCUSID
23414
ALIAS
DIH3,FOG2,SRXY9,ZC2HC11B,ZNF89B,hFOG-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23414
MIM: 603693
HGNC: 16700
Ensembl: ENSG00000169946

Variants:

dbSNP: 23414
ClinVar: 23414
TCGA: ENSG00000169946
COSMIC: ZFPM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169946ENST00000407775Q8WW38
ENSG00000169946ENST00000517361E7ET52
ENSG00000169946ENST00000520027E5RJX0
ENSG00000169946ENST00000520492E7ET52

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
200058032009Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K.112
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
126064182003FOG-2 and GATA-4 Are coexpressed in the mouse ovary and can modulate mullerian-inhibiting substance expression.31
208072242011New mutations in ZFPM2/FOG2 gene in tetralogy of Fallot and double outlet right ventricle.26
208072242011New mutations in ZFPM2/FOG2 gene in tetralogy of Fallot and double outlet right ventricle.26
219199012012Novel ZFPM2/FOG2 variants in patients with double outlet right ventricle.18
283731602017Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor.18
175683912007Candidate genes for congenital diaphragmatic hernia from animal models: sequencing of FOG2 and PDGFRalpha reveals rare variants in diaphragmatic hernia patients.17
245490392014Mutations in the FOG2/ZFPM2 gene are associated with anomalies of human testis determination.16
247024272015Prevalence and penetrance of ZFPM2 mutations and deletions causing congenital diaphragmatic hernia.13

Citation

Dessen P

ZFPM2 (zinc finger protein, FOG family member 2)

Atlas Genet Cytogenet Oncol Haematol. 2004-05-01

Online version: http://atlasgeneticsoncology.org/gene/431/zfpm2-(zinc-finger-protein-fog-family-member-2)