ADRA2B (adrenoceptor alpha 2B)

2006-10-01 Affiliation

Identity

HGNC

ADRA2B

LOCATION

2q11.2

LOCUSID

151

ALIAS

ADRA2L1,ADRA2RL1,ADRARL1,ALPHA2BAR,FAME2,alpha-2BAR

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 151
MIM: 104260
HGNC: 282
Ensembl: ENSG00000274286

Variants:

dbSNP: 151
ClinVar: 151
TCGA: ENSG00000274286
COSMIC: ADRA2B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000274286	ENST00000620793	P18089

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Platelet Aggregation (Plug Formation)	REACTOME	R-HSA-76009
Adrenaline signalling through Alpha-2 adrenergic receptor	REACTOME	R-HSA-392023
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Amine ligand-binding receptors	REACTOME	R-HSA-375280
Adrenoceptors	REACTOME	R-HSA-390696
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594
G alpha (z) signalling events	REACTOME	R-HSA-418597

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association
PA448665	brimonidine	Chemical	Pathway	associated
PA449051	clonidine	Chemical	Pathway	associated
PA449396	dopamine	Chemical	Pathway	associated
PA449470	epinephrine	Chemical	Pathway	associated
PA450121	isoproterenol	Chemical	Pathway	associated
PA450649	norepinephrine	Chemical	Pathway	associated
PA451946	yohimbine	Chemical	Pathway	associated

References

Pubmed ID	Year	Title	Citations
37525034	2023	ADRA2B and HTR1A: An Updated Study of the Biogenic Amine Receptors Reveals Novel Conserved Motifs Which Play Key Role in Mental Disorders.	2
37805907	2023	ASSOCIATION BETWEEN GLN27GLU POLYMORPHISM IN THE Β2 ADRENERGIC RECEPTOR GENE AND OBESITY RISK IN PATIENTS WITH EARLY-ONSET AND LATE-ONSET BRONCHIAL ASTHMA.	0
37525034	2023	ADRA2B and HTR1A: An Updated Study of the Biogenic Amine Receptors Reveals Novel Conserved Motifs Which Play Key Role in Mental Disorders.	2
37805907	2023	ASSOCIATION BETWEEN GLN27GLU POLYMORPHISM IN THE Β2 ADRENERGIC RECEPTOR GENE AND OBESITY RISK IN PATIENTS WITH EARLY-ONSET AND LATE-ONSET BRONCHIAL ASTHMA.	0
32385805	2021	Involvement of Histamine 2 Receptor in Alpha 1 Adrenoceptor Mediated Cardiac Hypertrophy and Oxidative Stress in H9c2 Cardio Myoblasts.	1
33900865	2021	Alpha-2 beta-adrenergic receptor (301-303 I/D) gene polymorphism in hypertension and type 2 diabetes mellitus diseases among Saudi cases in the Qassim region.	0
32385805	2021	Involvement of Histamine 2 Receptor in Alpha 1 Adrenoceptor Mediated Cardiac Hypertrophy and Oxidative Stress in H9c2 Cardio Myoblasts.	1
33900865	2021	Alpha-2 beta-adrenergic receptor (301-303 I/D) gene polymorphism in hypertension and type 2 diabetes mellitus diseases among Saudi cases in the Qassim region.	0
30858399	2019	Aging and the Combined effects of ADRA2B and CB1 deletions on Affective Working Memory.	1
31090375	2019	Interrelation of cardiovascular risk factors with high albuminury among patients with arterial hypertension living in Mountain Shoriya.	0
30858399	2019	Aging and the Combined effects of ADRA2B and CB1 deletions on Affective Working Memory.	1
31090375	2019	Interrelation of cardiovascular risk factors with high albuminury among patients with arterial hypertension living in Mountain Shoriya.	0
29212846	2018	Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population.	0
29751052	2018	ADRA2B deletion variant and enhanced cognitive processing of emotional information: A meta-analytical review.	8
29212846	2018	Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population.	0

Citation

Dessen P

ADRA2B (adrenoceptor alpha 2B)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43106/adra2b-(adrenoceptor-alpha-2b)