Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 157
MIM: 109636
HGNC: 290
Ensembl: ENSG00000100077
Variants:
dbSNP: 157
ClinVar: 157
TCGA: ENSG00000100077
COSMIC: GRK3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000100077 | ENST00000324198 | P35626 |
| ENSG00000100077 | ENST00000324198 | A0A024R1D8 |
| ENSG00000100077 | ENST00000455558 | H7C099 |
| ENSG00000100077 | ENST00000619906 | Q8N433 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA30616 | MAPK1 | Gene | Pathway | associated | |||
| PA39 | ADRB2 | Gene | Pathway | associated | |||
| PA62 | ATP1A1 | Gene | Pathway | associated | 23788015 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36907139 | 2023 | TEAD3 inhibits the proliferation and metastasis of prostate cancer via suppressing ADRBK2. | 1 |
| 37048054 | 2023 | Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget's Disease of Bone. | 0 |
| 37543278 | 2023 | A novel GRK3-HDAC2 regulatory pathway is a key direct link between neuroendocrine differentiation and angiogenesis in prostate cancer progression. | 1 |
| 36907139 | 2023 | TEAD3 inhibits the proliferation and metastasis of prostate cancer via suppressing ADRBK2. | 1 |
| 37048054 | 2023 | Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget's Disease of Bone. | 0 |
| 37543278 | 2023 | A novel GRK3-HDAC2 regulatory pathway is a key direct link between neuroendocrine differentiation and angiogenesis in prostate cancer progression. | 1 |
| 33060647 | 2020 | Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells. | 18 |
| 33060647 | 2020 | Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells. | 18 |
| 31604529 | 2019 | The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on β-adrenoceptors. | 4 |
| 31604529 | 2019 | The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on β-adrenoceptors. | 4 |
| 29254792 | 2018 | High expression of GRK3 is associated with favorable prognosis in pancreatic ductal adenocarcinoma. | 5 |
| 29254792 | 2018 | High expression of GRK3 is associated with favorable prognosis in pancreatic ductal adenocarcinoma. | 5 |
| 29445249 | 2017 | Overexpression of GRK3, Promoting Tumor Proliferation, Is Predictive of Poor Prognosis in Colon Cancer. | 8 |
| 29445249 | 2017 | Overexpression of GRK3, Promoting Tumor Proliferation, Is Predictive of Poor Prognosis in Colon Cancer. | 8 |
| 27049755 | 2016 | G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis. | 29 |
Citation
Dessen P
GRK3 (G protein-coupled receptor kinase 3)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43107/gene-fusions-explorer/meetings/
