AK1 (adenylate kinase 1)

2006-10-01  

Identity

HGNC
LOCATION
9q34.11
LOCUSID
ALIAS
HTL-S-58j

Other Information

Locus ID:

NCBI: 203
MIM: 103000
HGNC: 361
Ensembl: ENSG00000106992

Variants:

dbSNP: 203
ClinVar: 203
TCGA: ENSG00000106992
COSMIC: AK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106992ENST00000223836Q5T9B7
ENSG00000106992ENST00000373156P00568
ENSG00000106992ENST00000373156Q6FGX9
ENSG00000106992ENST00000550143H0YID2
ENSG00000106992ENST00000550992F8VRY5
ENSG00000106992ENST00000644144P00568
ENSG00000106992ENST00000644144Q6FGX9

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Thiamine metabolismKEGGko00730
Purine metabolismKEGGhsa00230
Thiamine metabolismKEGGhsa00730
Metabolic pathwaysKEGGhsa01100
Adenine ribonucleotide biosynthesis, IMP => ADP,ATPKEGGM00049
Adenine ribonucleotide biosynthesis, IMP => ADP,ATPKEGGhsa_M00049
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Synthesis and interconversion of nucleotide di- and triphosphatesREACTOMER-HSA-499943

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
238636342013AMPK, insulin resistance, and the metabolic syndrome.207
191655272009Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.56
244958782014The many isoforms of human adenylate kinases.27
224197362012Neuropathogenic role of adenylate kinase-1 in Aβ-mediated tau phosphorylation via AMPK and GSK3β.17
226375332012Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities.17
167142922006Ectoadenylate kinase and plasma membrane ATP synthase activities of human vascular endothelial cells.7
214570042011The adipokine zinc-α2-glycoprotein activates AMP kinase in human primary skeletal muscle cells.5
314093842019DNA methylation signature is prognostic of choroid plexus tumor aggressiveness.5
184045682008Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.4
126491622003Red cell adenylate kinase deficiency: molecular study of 3 new mutations (118G>A, 190G>A, and GAC deletion) associated with hereditary nonspherocytic hemolytic anemia.2

Citation

Dessen P

AK1 (adenylate kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43111/ak1-(adenylate-kinase-1)