Identity
HGNC
LOCATION
6q22.33
LOCUSID
ALIAS
MacGAP,SENEX,bA307O14.2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 93663
MIM: 613351
HGNC: 21035
Ensembl: ENSG00000146376
Variants:
dbSNP: 93663
ClinVar: 93663
TCGA: ENSG00000146376
COSMIC: ARHGAP18
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000146376 | ENST00000368149 | Q8N392 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by Rho GTPases | REACTOME | R-HSA-194315 |
| Rho GTPase cycle | REACTOME | R-HSA-194840 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37171759 | 2024 | ARHGAP18 is Upregulated by Transcription Factor GATA1 Promotes the Proliferation and Invasion in Hepatocellular Carcinoma. | 1 |
| 37171759 | 2024 | ARHGAP18 is Upregulated by Transcription Factor GATA1 Promotes the Proliferation and Invasion in Hepatocellular Carcinoma. | 1 |
| 31776727 | 2020 | A novel SNP rs11759328 on Rho GTPase-activating protein 18 gene is associated with the expression of Hb F in hemoglobin E-related disorders. | 2 |
| 32013974 | 2020 | YAP and the RhoC regulator ARHGAP18, are required to mediate flow-dependent endothelial cell alignment. | 12 |
| 33092266 | 2020 | A Screen for PKN3 Substrates Reveals an Activating Phosphorylation of ARHGAP18. | 2 |
| 31776727 | 2020 | A novel SNP rs11759328 on Rho GTPase-activating protein 18 gene is associated with the expression of Hb F in hemoglobin E-related disorders. | 2 |
| 32013974 | 2020 | YAP and the RhoC regulator ARHGAP18, are required to mediate flow-dependent endothelial cell alignment. | 12 |
| 33092266 | 2020 | A Screen for PKN3 Substrates Reveals an Activating Phosphorylation of ARHGAP18. | 2 |
| 28709956 | 2018 | Activation of human gonadotropin-releasing hormone receptor promotes down regulation of ARHGAP18 and regulates the cell invasion of MDA-MB-231 cells. | 4 |
| 28983712 | 2018 | ARHGAP18 is a novel gene under positive natural selection that influences HbF levels in β-thalassaemia. | 2 |
| 30510148 | 2018 | LncRNA CDKN2BAS predicts poor prognosis in patients with hepatocellular carcinoma and promotes metastasis via the miR-153-5p/ARHGAP18 signaling axis. | 60 |
| 28709956 | 2018 | Activation of human gonadotropin-releasing hormone receptor promotes down regulation of ARHGAP18 and regulates the cell invasion of MDA-MB-231 cells. | 4 |
| 28983712 | 2018 | ARHGAP18 is a novel gene under positive natural selection that influences HbF levels in β-thalassaemia. | 2 |
| 30510148 | 2018 | LncRNA CDKN2BAS predicts poor prognosis in patients with hepatocellular carcinoma and promotes metastasis via the miR-153-5p/ARHGAP18 signaling axis. | 60 |
| 28251925 | 2017 | The RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cells. | 12 |
Citation
Dessen P
ARHGAP18 (Rho GTPase activating protein 18)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43135/arhgap18-(rho-gtpase-activating-protein-18)
