ARHGAP22 (Rho GTPase activating protein 22)

2006-10-01  

Identity

HGNC
ARHGAP22
LOCATION
10q11.22
LOCUSID
58504
ALIAS
RhoGAP2,RhoGap22
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 58504
MIM: 610585
HGNC: 30320
Ensembl: ENSG00000128805

Variants:

dbSNP: 58504
ClinVar: 58504
TCGA: ENSG00000128805
COSMIC: ARHGAP22

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128805ENST00000249601Q7Z5H3
ENSG00000128805ENST00000374170A6NJ38
ENSG00000128805ENST00000374172A6NHM7
ENSG00000128805ENST00000417247Q7Z5H3
ENSG00000128805ENST00000417912Q7Z5H3
ENSG00000128805ENST00000417912A0A2X0SFC0
ENSG00000128805ENST00000435790Q7Z5H3
ENSG00000128805ENST00000460425D6RBJ8
ENSG00000128805ENST00000477708D6R9V6

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
364561172022Endosomal Localization of RacGAP Protein ARHGAP22 Regulates its GAP Activity in Human Melanoma Cells.0
364561172022Endosomal Localization of RacGAP Protein ARHGAP22 Regulates its GAP Activity in Human Melanoma Cells.0
316027022020DNA hypermethylation is associated with invasive phenotype of malignant melanoma.29
319767612020Associations of rs2300782 CAMK4, rs2292239 ERBB3 and rs10491034 ARHGAP22 with Diabetic Retinopathy Among Chinese Hui Population.0
316027022020DNA hypermethylation is associated with invasive phenotype of malignant melanoma.29
319767612020Associations of rs2300782 CAMK4, rs2292239 ERBB3 and rs10491034 ARHGAP22 with Diabetic Retinopathy Among Chinese Hui Population.0
285445092017Association of ARHGAP22 gene polymorphisms with the risk of type 2 diabetic retinopathy.0
285445092017Association of ARHGAP22 gene polymorphisms with the risk of type 2 diabetic retinopathy.0
229525832012The weak complex between RhoGAP protein ARHGAP22 and signal regulatory protein 14-3-3 has 1:2 stoichiometry and a single peptide binding mode.5
229525832012The weak complex between RhoGAP protein ARHGAP22 and signal regulatory protein 14-3-3 has 1:2 stoichiometry and a single peptide binding mode.5
213104922011Genome-wide association study of diabetic retinopathy in a Taiwanese population.58
219264142011The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPδ and RhoGAP2.49
219696042011Identification of RhoGAP22 as an Akt-dependent regulator of cell motility in response to insulin.7
213104922011Genome-wide association study of diabetic retinopathy in a Taiwanese population.58
219264142011The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPδ and RhoGAP2.49

Citation

Dessen P

ARHGAP22 (Rho GTPase activating protein 22)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43138/haematological-explorer/favicon/humanGenome