ARHGEF17 (Rho guanine nucleotide exchange factor 17)

2006-10-01  

Identity

HGNC
LOCATION
11q13.4
LOCUSID
ALIAS
P164RHOGEF,RHOGEF17,TEM4,p164-RhoGEF
FUSION GENES

Other Information

Locus ID:

NCBI: 9828
MIM: 617043
HGNC: 21726
Ensembl: ENSG00000110237

Variants:

dbSNP: 9828
ClinVar: 9828
TCGA: ENSG00000110237
COSMIC: ARHGEF17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110237ENST00000263674Q96PE2
ENSG00000110237ENST00000544519H0YFZ8
ENSG00000110237ENST00000643371A0A2R8Y4D7

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
120718592002A mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF) without a pleckstrin homology domain.12
229118622012Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4.11
186777702008Identification of ARHGEF17, DENND2D, FGFR3, and RB1 mutations in melanoma by inhibition of nonsense-mediated mRNA decay.10
231958292013RhoGEF17, a Rho-specific guanine nucleotide exchange factor activated by phosphorylation via cyclic GMP-dependent kinase Iα.6
269533502016ARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochores.6
199110112010Mutation of ARHGAP9 in patients with coronary spastic angina.5
238250012013The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility.5
299972252018Rho Guanine Nucleotide Exchange Factor ARHGEF17 Is a Risk Gene for Intracranial Aneurysms.2

Citation

Dessen P

ARHGEF17 (Rho guanine nucleotide exchange factor 17)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43147/arhgef17-(rho-guanine-nucleotide-exchange-factor-17)