ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18)

2006-10-01 Affiliation

Identity

HGNC

ARHGEF18

LOCATION

19p13.2

LOCUSID

23370

ALIAS

P114-RhoGEF,RP78,SA-RhoGEF,p114RhoGEF

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 23370
MIM: 616432
HGNC: 17090
Ensembl: ENSG00000268861

Variants:

dbSNP: 23370
ClinVar: 23370
TCGA: ENSG00000268861
COSMIC: ARHGEF18

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000268861	ENST00000668164	A0A590UK10

Pathways

Pathway	Source	External ID
Tight junction	KEGG	ko04530
Tight junction	KEGG	hsa04530
Signal Transduction	REACTOME	R-HSA-162582
Signalling by NGF	REACTOME	R-HSA-166520
p75 NTR receptor-mediated signalling	REACTOME	R-HSA-193704
Cell death signalling via NRAGE, NRIF and NADE	REACTOME	R-HSA-204998
NRAGE signals death through JNK	REACTOME	R-HSA-193648
Signaling by Rho GTPases	REACTOME	R-HSA-194315
Rho GTPase cycle	REACTOME	R-HSA-194840
Signaling by TGF-beta Receptor Complex	REACTOME	R-HSA-170834
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	REACTOME	R-HSA-2173791
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (12/13) signalling events	REACTOME	R-HSA-416482

References

Pubmed ID	Year	Title	Citations
29601110	2018	Expression of novel "LOCGEF" isoforms of ARHGEF18 in eosinophils.	2
30405854	2018	Association between a Single Nucleotide Polymorphism in the 3'-UTR of ARHGEF18 and the Risk of Nonidiopathic Pulmonary Arterial Hypertension in Chinese Population.	4
29601110	2018	Expression of novel "LOCGEF" isoforms of ARHGEF18 in eosinophils.	2
30405854	2018	Association between a Single Nucleotide Polymorphism in the 3'-UTR of ARHGEF18 and the Risk of Nonidiopathic Pulmonary Arterial Hypertension in Chinese Population.	4
28132693	2017	Biallelic Mutation of ARHGEF18, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration.	13
28132693	2017	Biallelic Mutation of ARHGEF18, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration.	13
26217016	2015	CRB3A Controls the Morphology and Cohesion of Cancer Cells through Ehm2/p114RhoGEF-Dependent Signaling.	13
26217016	2015	CRB3A Controls the Morphology and Cohesion of Cancer Cells through Ehm2/p114RhoGEF-Dependent Signaling.	13
23648482	2013	LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation.	30
23648482	2013	LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation.	30
23185572	2012	Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion.	25
23185572	2012	Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion.	25
21258369	2011	Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis.	123
22006950	2011	Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF.	47
21258369	2011	Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis.	123

Citation

Dessen P

ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43148/arhgef18-(rho-rac-guanine-nucleotide-exchange-factor-18)

Cookies