ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18)

2006-10-01  

Identity

HGNC
ARHGEF18
LOCATION
19p13.2
LOCUSID
23370
ALIAS
P114-RhoGEF,RP78,SA-RhoGEF,p114RhoGEF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23370
MIM: 616432
HGNC: 17090
Ensembl: ENSG00000268861

Variants:

dbSNP: 23370
ClinVar: 23370
TCGA: ENSG00000268861
COSMIC: ARHGEF18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000268861ENST00000668164A0A590UK10

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)REACTOMER-HSA-2173791
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482

References

Pubmed IDYearTitleCitations
296011102018Expression of novel "LOCGEF" isoforms of ARHGEF18 in eosinophils.2
304058542018Association between a Single Nucleotide Polymorphism in the 3'-UTR of ARHGEF18 and the Risk of Nonidiopathic Pulmonary Arterial Hypertension in Chinese Population.4
296011102018Expression of novel "LOCGEF" isoforms of ARHGEF18 in eosinophils.2
304058542018Association between a Single Nucleotide Polymorphism in the 3'-UTR of ARHGEF18 and the Risk of Nonidiopathic Pulmonary Arterial Hypertension in Chinese Population.4
281326932017Biallelic Mutation of ARHGEF18, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration.13
281326932017Biallelic Mutation of ARHGEF18, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration.13
262170162015CRB3A Controls the Morphology and Cohesion of Cancer Cells through Ehm2/p114RhoGEF-Dependent Signaling.13
262170162015CRB3A Controls the Morphology and Cohesion of Cancer Cells through Ehm2/p114RhoGEF-Dependent Signaling.13
236484822013LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation.30
236484822013LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation.30
231855722012Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion.25
231855722012Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion.25
212583692011Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis.123
220069502011Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF.47
212583692011Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis.123

Citation

Dessen P

ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43148/arhgef18-(rho-rac-guanine-nucleotide-exchange-factor-18)