Identity
HGNC
LOCATION
Xq26.3
LOCUSID
ALIAS
COOL2,Cool-2,MRX46,PIXA,alpha-PIX,alphaPIX
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9459
MIM: 300267
HGNC: 685
Ensembl: ENSG00000129675
Variants:
dbSNP: 9459
ClinVar: 9459
TCGA: ENSG00000129675
COSMIC: ARHGEF6
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000129675 | ENST00000250617 | Q15052 |
| ENSG00000129675 | ENST00000370620 | Q15052 |
| ENSG00000129675 | ENST00000370622 | Q15052 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36414417 | 2023 | Genetic Variants in ARHGEF6 Cause Congenital Anomalies of the Kidneys and Urinary Tract in Humans, Mice, and Frogs. | 1 |
| 36586227 | 2023 | Comprehensive analysis identifies ARHGEF6 as a potential prognostic and immunological biomarker in lung adenocarcinoma. | 2 |
| 37027440 | 2023 | Clinical implication and potential function of ARHGEF6 in acute myeloid leukemia: An in vitro study. | 0 |
| 37058762 | 2023 | The pathological significance and potential mechanism of ARHGEF6 in lung adenocarcinoma. | 0 |
| 36414417 | 2023 | Genetic Variants in ARHGEF6 Cause Congenital Anomalies of the Kidneys and Urinary Tract in Humans, Mice, and Frogs. | 1 |
| 36586227 | 2023 | Comprehensive analysis identifies ARHGEF6 as a potential prognostic and immunological biomarker in lung adenocarcinoma. | 2 |
| 37027440 | 2023 | Clinical implication and potential function of ARHGEF6 in acute myeloid leukemia: An in vitro study. | 0 |
| 37058762 | 2023 | The pathological significance and potential mechanism of ARHGEF6 in lung adenocarcinoma. | 0 |
| 28333213 | 2017 | X Chromosome-wide Association Study Identifies a Susceptibility Locus for Inflammatory Bowel Disease in Koreans. | 3 |
| 28333213 | 2017 | X Chromosome-wide Association Study Identifies a Susceptibility Locus for Inflammatory Bowel Disease in Koreans. | 3 |
| 27182061 | 2016 | Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes. | 63 |
| 27182061 | 2016 | Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes. | 63 |
| 26177020 | 2015 | αPIX Is a Trafficking Regulator that Balances Recycling and Degradation of the Epidermal Growth Factor Receptor. | 3 |
| 26507661 | 2015 | Cyclic Nucleotide-dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets. | 18 |
| 26177020 | 2015 | αPIX Is a Trafficking Regulator that Balances Recycling and Degradation of the Epidermal Growth Factor Receptor. | 3 |
Citation
Dessen P
ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43152/arhgef6-(rac-cdc42-guanine-nucleotide-exchange-factor-6)
