BCL2L13 (BCL2 like 13)

2006-10-01  

Identity

HGNC
BCL2L13
LOCATION
22q11.21
LOCUSID
23786
ALIAS
BCL-RAMBO,Bcl2-L-13,MIL1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23786
HGNC: 17164
Ensembl: ENSG00000099968

Variants:

dbSNP: 23786
ClinVar: 23786
TCGA: ENSG00000099968
COSMIC: BCL2L13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099968ENST00000317582Q9BXK5
ENSG00000099968ENST00000337612A0A0A0MR90
ENSG00000099968ENST00000355028E9PDD6
ENSG00000099968ENST00000399777H0Y3R5
ENSG00000099968ENST00000399782Q9BXK5
ENSG00000099968ENST00000418951Q9BXK5
ENSG00000099968ENST00000493680Q9BXK5
ENSG00000099968ENST00000498133F2Z2C3
ENSG00000099968ENST00000538149F6VJB4
ENSG00000099968ENST00000543133Q9BXK5
ENSG00000099968ENST00000611738A0A087WTL4
ENSG00000099968ENST00000616863A0A087WW80
ENSG00000099968ENST00000618481A0A087WX97

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
261463852015Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation.92
173603632007Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family.90
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
247068052014Bcl2L13 is a ceramide synthase inhibitor in glioblastoma.24
190645712008Polymorphisms in mitochondrial genes and prostate cancer risk.20
208555362010Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma.18
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
125273622003Bcl-rambo beta, a special splicing variant with an insertion of an Alu-like cassette, promotes etoposide- and Taxol-induced cell death.12

Citation

Dessen P

BCL2L13 (BCL2 like 13)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43163/bcl2l13-(bcl2-like-13)