BRSK1 (BR serine/threonine kinase 1)

2006-10-01 Affiliation

Identity

HGNC

BRSK1

LOCATION

19q13.42

LOCUSID

84446

ALIAS

hSAD1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 84446
MIM: 609235
HGNC: 18994
Ensembl: ENSG00000160469

Variants:

dbSNP: 84446
ClinVar: 84446
TCGA: ENSG00000160469
COSMIC: BRSK1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000160469	ENST00000309383	Q8TDC3
ENSG00000160469	ENST00000326848	J3KNK0
ENSG00000160469	ENST00000585418	Q8TDC3
ENSG00000160469	ENST00000590333	Q8TDC3
ENSG00000160469	ENST00000591774	K7EM68
ENSG00000160469	ENST00000592539	K7EN26

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37140697	2023	BRSK1 confers cisplatin resistance in cervical cancer cells via regulation of mitochondrial respiration.	1
37140697	2023	BRSK1 confers cisplatin resistance in cervical cancer cells via regulation of mitochondrial respiration.	1
31895179	2020	Relationship between BRSK1 rs12611091 variant and age at natural menopause based on physical activity.	0
31895179	2020	Relationship between BRSK1 rs12611091 variant and age at natural menopause based on physical activity.	0
27677186	2016	Putative Tumor Suppressor Genes EGR1 and BRSK1 Are Mutated in Gastric and Colorectal Cancers.	11
27677186	2016	Putative Tumor Suppressor Genes EGR1 and BRSK1 Are Mutated in Gastric and Colorectal Cancers.	11
25036402	2014	Decreased expression and prognostic role of cytoplasmic BRSK1 in human breast carcinoma: correlation with Jab1 stability and PI3K/Akt pathway.	5
25036402	2014	Decreased expression and prognostic role of cytoplasmic BRSK1 in human breast carcinoma: correlation with Jab1 stability and PI3K/Akt pathway.	5
22131368	2012	Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women's Health Initiative SHARe Study.	42
22131368	2012	Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women's Health Initiative SHARe Study.	42
18854318	2009	C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.	33
19448619	2009	Loci at chromosomes 13, 19 and 20 influence age at natural menopause.	76
19448621	2009	Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.	180
19648910	2009	SADB phosphorylation of gamma-tubulin regulates centrosome duplication.	41
18854318	2009	C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.	33

Citation

Dessen P

BRSK1 (BR serine/threonine kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43173/brsk1-(br-serine-threonine-kinase-1)