BRSK2 (BR serine/threonine kinase 2)

2006-10-01  

Identity

HGNC
LOCATION
11p15.5
LOCUSID
ALIAS
C11orf7,PEN11B,SAD1,SADA,STK29
FUSION GENES

Other Information

Locus ID:

NCBI: 9024
MIM: 609236
HGNC: 11405
Ensembl: ENSG00000174672

Variants:

dbSNP: 9024
ClinVar: 9024
TCGA: ENSG00000174672
COSMIC: BRSK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174672ENST00000308219Q8IWQ3
ENSG00000174672ENST00000308219A0A140VJF6
ENSG00000174672ENST00000382179Q8IWQ3
ENSG00000174672ENST00000524702E9PPI2
ENSG00000174672ENST00000526678Q8IWQ3
ENSG00000174672ENST00000528596E9PRY3
ENSG00000174672ENST00000528710Q8IWQ3
ENSG00000174672ENST00000528841Q8IWQ3
ENSG00000174672ENST00000529433Q8IWQ3
ENSG00000174672ENST00000529433A0A024RCE9
ENSG00000174672ENST00000529951H0YCS6
ENSG00000174672ENST00000531197Q8IWQ3
ENSG00000174672ENST00000531197A0A024RCE9
ENSG00000174672ENST00000533606H0YES6
ENSG00000174672ENST00000544817A0A0C4DGH9

Expression (GTEx)

0
50
100
150

References

Pubmed IDYearTitleCitations
188543182009C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.29
227980682012Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic β-cells.16
183396222008Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation.14
187943422008The Tsc1-Tsc2 complex influences neuronal polarity by modulating TORC1 activity and SAD levels.12
161652222005BR serine/threonine kinase 2: a new autoantigen in paraneoplastic limbic encephalitis.9
168701372006BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260.8
227134622012BRSK2 is regulated by ER stress in protein level and involved in ER stress-induced apoptosis.8
230293252012APC/C(Cdh1) targets brain-specific kinase 2 (BRSK2) for degradation via the ubiquitin-proteasome pathway.6
285917202017BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity.5
226093992012Jab1 interacts with brain-specific kinase 2 (BRSK2) and promotes its degradation in the ubiquitin-proteasome pathway.4

Citation

Dessen P

BRSK2 (BR serine/threonine kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43174/brsk2-(br-serine-threonine-kinase-2)