CAMK2A (calcium/calmodulin dependent protein kinase II alpha)

2006-10-01

Identity

HGNC

CAMK2A

LOCATION

5q32

LOCUSID

815

ALIAS

CAMKA,CaMKIINalpha,CaMKIIalpha,MRD53,MRT63

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 815
MIM: 114078
HGNC: 1460
Ensembl: ENSG00000070808

Variants:

dbSNP: 815
ClinVar: 815
TCGA: ENSG00000070808
COSMIC: CAMK2A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000070808	ENST00000348628	Q9UQM7
ENSG00000070808	ENST00000348628	Q7LDD5
ENSG00000070808	ENST00000398376	Q9UQM7
ENSG00000070808	ENST00000510347	D6RFJ0
ENSG00000070808	ENST00000671881	A8K161
ENSG00000070808	ENST00000672479	Q7LDD5

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Expression (GTEx)

100

200

300

400

500

600

700

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Activation of NMDA receptor upon glutamate binding and postsynaptic events	REACTOME	R-HSA-442755
Adrenergic signaling in cardiomyocytes	KEGG	hsa04261
Adrenergic signaling in cardiomyocytes	KEGG	ko04261
Aldosterone synthesis and secretion	KEGG	hsa04925
Aldosterone synthesis and secretion	KEGG	ko04925
Amphetamine addiction	KEGG	hsa05031
Amphetamine addiction	KEGG	ko05031
ARMS-mediated activation	REACTOME	R-HSA-170984
Axon guidance	KEGG	ko04360
Axon guidance	KEGG	hsa04360

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association
PA248	NFKB1	Gene	Pathway	associated
PA27749	ELK1	Gene	Pathway	associated
PA28212	FOS	Gene	Pathway	associated
PA296	RELA	Gene	Pathway	associated
PA30006	JUN	Gene	Pathway	associated
PA31353	MYC	Gene	Pathway	associated
PA31600	NFKB2	Gene	Pathway	associated
PA337	STAT3	Gene	Pathway	associated
PA338	STAT5A	Gene	Pathway	associated
PA36042	SP1	Gene	Pathway	associated

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References

Pubmed ID	Year	Title	Citations
31750928	2020	Regular Aerobic Exercise-Alleviated Dysregulation of CAMKIIα Carbonylation to Mitigate Parkinsonism via Homeostasis of Apoptosis With Autophagy.	4
32149607	2020	Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation.	23
32418901	2020	Association of a CAMK2A genetic variant with logical memory performance and hippocampal volume in the elderly.	1
32483123	2020	CAMK2A supported tumor initiating cells of lung adenocarcinoma by upregulating SOX2 through EZH2 phosphorylation.	8
32580140	2020	Nanoscale regulation of L-type calcium channels differentiates between ischemic and dilated cardiomyopathies.	11
32611770	2020	CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability.	12
32685443	2020	Role of Oxidation-Dependent CaMKII Activation in the Genesis of Abnormal Action Potentials in Atrial Cardiomyocytes: A Simulation Study.	7
33707504	2021	Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis.	8
33707504	2021	Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis.	8
34607601	2021	Association of CaMK2A and MeCP2 signaling pathways with cognitive ability in adolescents.	3

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Citation

Dessen P

CAMK2A (calcium/calmodulin dependent protein kinase II alpha)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43181