CARD9 (caspase recruitment domain family member 9)

2006-10-01  

Identity

HGNC
CARD9
LOCATION
9q34.3
LOCUSID
64170
ALIAS
CANDF2,hCARD9

Other Information

Locus ID:

NCBI: 64170
MIM: 607212
HGNC: 16391
Ensembl: ENSG00000187796

Variants:

dbSNP: 64170
ClinVar: 64170
TCGA: ENSG00000187796
COSMIC: CARD9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187796ENST00000371732Q9H257
ENSG00000187796ENST00000371732A0A024R8F1
ENSG00000187796ENST00000371734Q9H257
ENSG00000187796ENST00000489932Q9H257
ENSG00000187796ENST00000489932A0A024R8I4
ENSG00000187796ENST00000641290A0A286YFD5

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysREACTOMER-HSA-168643
NOD1/2 Signaling PathwayREACTOMER-HSA-168638
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
CLEC7A (Dectin-1) signalingREACTOMER-HSA-5607764

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384738452024Role of CARD9 in Cell- and Organ-Specific Immune Responses in Various Infections.1
384830732024CARD9 mutations in patients with fungal infections: An update from the last 5 years.0
384738452024Role of CARD9 in Cell- and Organ-Specific Immune Responses in Various Infections.1
384830732024CARD9 mutations in patients with fungal infections: An update from the last 5 years.0
357388982023Mesenchymal stem cells regulate M1 polarization of peritoneal macrophages through the CARD9-NF-κB signaling pathway in severe acute pancreatitis.2
367186292023CARD9 balances Aspergillus fumigatus-induced anti-fungal immunity and allergic inflammation.0
367822982023Genetic association of PRKCD and CARD9 polymorphisms with Vogt-Koyanagi-Harada disease in the Chinese Han population.0
370622852023Polymorphisms of CARD9 Gene Predict Disease Progression and Renal Survival of Immunoglobulin A Nephropathy.1
370852642023CARD9, VAV3, and infection risk in IgA nephropathy.1
372131602023Expression of mir-25-3p, CARD9 and Surviving in Acute Pancreatitis and Predictive Value for Patient Outcome.0
374612352023Heterozygous CARD9 mutation favors the development of allergic bronchopulmonary aspergillosis.0
379911972023Regulatory roles of CARD9-BCL10-Rac1 (CBR) signalome in islet β-cell function in health and metabolic stress: Is there room for MALT1?1
357388982023Mesenchymal stem cells regulate M1 polarization of peritoneal macrophages through the CARD9-NF-κB signaling pathway in severe acute pancreatitis.2
367186292023CARD9 balances Aspergillus fumigatus-induced anti-fungal immunity and allergic inflammation.0
367822982023Genetic association of PRKCD and CARD9 polymorphisms with Vogt-Koyanagi-Harada disease in the Chinese Han population.0

Citation

Dessen P

CARD9 (caspase recruitment domain family member 9)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43193/card9-(caspase-recruitment-domain-family-member-9)