CCNT2 (cyclin T2)

2006-10-01 Affiliation

Identity

HGNC

CCNT2

LOCATION

2q21.3

LOCUSID

905

ALIAS

CYCT2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 905
MIM: 603862
HGNC: 1600
Ensembl: ENSG00000082258

Variants:

dbSNP: 905
ClinVar: 905
TCGA: ENSG00000082258
COSMIC: CCNT2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000082258	ENST00000264157	O60583
ENSG00000082258	ENST00000295238	O60583
ENSG00000082258	ENST00000417175	F8WDY7
ENSG00000082258	ENST00000419781	F2Z2C9
ENSG00000082258	ENST00000438691	H7C411
ENSG00000082258	ENST00000446247	C9JUL2
ENSG00000082258	ENST00000452521	H7BZ27
ENSG00000082258	ENST00000452839	F2Z2C9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Transcriptional misregulation in cancer	KEGG	ko05202
Transcriptional misregulation in cancer	KEGG	hsa05202
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
HIV Infection	REACTOME	R-HSA-162906
HIV Life Cycle	REACTOME	R-HSA-162587
Late Phase of HIV Life Cycle	REACTOME	R-HSA-162599
Transcription of the HIV genome	REACTOME	R-HSA-167172
HIV elongation arrest and recovery	REACTOME	R-HSA-167287
Formation of HIV elongation complex in the absence of HIV Tat	REACTOME	R-HSA-167152
Pausing and recovery of HIV elongation	REACTOME	R-HSA-167290
Signal Transduction	REACTOME	R-HSA-162582
Signaling by TGF-beta Receptor Complex	REACTOME	R-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	REACTOME	R-HSA-2173793
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	REACTOME	R-HSA-2173796
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
RNA Polymerase II Transcription	REACTOME	R-HSA-73857
RNA Polymerase II Pre-transcription Events	REACTOME	R-HSA-674695
RNA Polymerase II Transcription Elongation	REACTOME	R-HSA-75955
Formation of RNA Pol II elongation complex	REACTOME	R-HSA-112382
TP53 Regulates Transcription of DNA Repair Genes	REACTOME	R-HSA-6796648
RNA polymerase II transcribes snRNA genes	REACTOME	R-HSA-6807505

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
31957815	2020	MiRNA-188-5p alleviates the progression of osteosarcoma via target degrading CCNT2.	7
31957815	2020	MiRNA-188-5p alleviates the progression of osteosarcoma via target degrading CCNT2.	7
28409330	2017	MicroRNA-192 regulates cell proliferation and cell cycle transition in acute myeloid leukemia via interaction with CCNT2.	17
28409330	2017	MicroRNA-192 regulates cell proliferation and cell cycle transition in acute myeloid leukemia via interaction with CCNT2.	17
24515107	2014	Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.	39
24515107	2014	Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.	39
19883659	2010	Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA.	15
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
19883659	2010	Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA.	15
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
18391197	2008	TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb.	26
18391197	2008	TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb.	26
16841087	2007	Abrogation of signal-dependent activation of the cdk9/cyclin T2a complex in human RD rhabdomyosarcoma cells.	10
17452463	2007	Regulation of P-TEFb elongation complex activity by CDK9 acetylation.	43
16841087	2007	Abrogation of signal-dependent activation of the cdk9/cyclin T2a complex in human RD rhabdomyosarcoma cells.	10

Citation

Dessen P

CCNT2 (cyclin T2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43195/ccnt2-(cyclin-t2)