CDC42BPA (CDC42 binding protein kinase alpha)

2006-10-01  

Identity

HGNC
CDC42BPA
LOCATION
1q42.13
LOCUSID
8476
ALIAS
MRCK,MRCKA,PK428
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8476
MIM: 603412
HGNC: 1737
Ensembl: ENSG00000143776

Variants:

dbSNP: 8476
ClinVar: 8476
TCGA: ENSG00000143776
COSMIC: CDC42BPA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143776ENST00000334218Q5VT25
ENSG00000143776ENST00000366764A0A0A0MRJ0
ENSG00000143776ENST00000366766A0A0A0MRJ1
ENSG00000143776ENST00000366767Q5VT25
ENSG00000143776ENST00000366769Q5VT25
ENSG00000143776ENST00000429440H0Y6R0
ENSG00000143776ENST00000441725H0Y6V3
ENSG00000143776ENST00000442054H0Y5V1
ENSG00000143776ENST00000448940H0Y7V8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
352032702022MRCK-Alpha and Its Effector Myosin II Regulatory Light Chain Bind ABCB4 and Regulate Its Membrane Expression.1
352032702022MRCK-Alpha and Its Effector Myosin II Regulatory Light Chain Bind ABCB4 and Regulate Its Membrane Expression.1
334764372021Myotonic dystrophy kinase-related CDC42-binding kinase α, a new transferrin receptor type 2-binding partner, is a regulator of erythropoiesis.1
335078842021The Na+, K+-ATPase β1 subunit regulates epithelial tight junctions via MRCKα.9
337844402021Effect and in silico characterization of genetic variants associated with severe spermatogenic disorders in a large Iberian cohort.9
346753262021Gene transfer of MRCKα rescues lipopolysaccharide-induced acute lung injury by restoring alveolar capillary barrier function.3
334764372021Myotonic dystrophy kinase-related CDC42-binding kinase α, a new transferrin receptor type 2-binding partner, is a regulator of erythropoiesis.1
335078842021The Na+, K+-ATPase β1 subunit regulates epithelial tight junctions via MRCKα.9
337844402021Effect and in silico characterization of genetic variants associated with severe spermatogenic disorders in a large Iberian cohort.9
346753262021Gene transfer of MRCKα rescues lipopolysaccharide-induced acute lung injury by restoring alveolar capillary barrier function.3
320711692020Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma.15
320711692020Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma.15
290729162018Comparative Proteomics Analysis Identifies Cdc42-Cdc42BPA Signaling as Prognostic Biomarker and Therapeutic Target for Colon Cancer Invasion.10
291626242018MRCKα is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion.15
290729162018Comparative Proteomics Analysis Identifies Cdc42-Cdc42BPA Signaling as Prognostic Biomarker and Therapeutic Target for Colon Cancer Invasion.10

Citation

Dessen P

CDC42BPA (CDC42 binding protein kinase alpha)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43197/cdc42bpa-(cdc42-binding-protein-kinase-alpha)