Identity
HGNC
LOCATION
1q42.13
LOCUSID
ALIAS
MRCK,MRCKA,PK428
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8476
MIM: 603412
HGNC: 1737
Ensembl: ENSG00000143776
Variants:
dbSNP: 8476
ClinVar: 8476
TCGA: ENSG00000143776
COSMIC: CDC42BPA
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35203270 | 2022 | MRCK-Alpha and Its Effector Myosin II Regulatory Light Chain Bind ABCB4 and Regulate Its Membrane Expression. | 1 |
| 35203270 | 2022 | MRCK-Alpha and Its Effector Myosin II Regulatory Light Chain Bind ABCB4 and Regulate Its Membrane Expression. | 1 |
| 33476437 | 2021 | Myotonic dystrophy kinase-related CDC42-binding kinase α, a new transferrin receptor type 2-binding partner, is a regulator of erythropoiesis. | 1 |
| 33507884 | 2021 | The Na+, K+-ATPase β1 subunit regulates epithelial tight junctions via MRCKα. | 9 |
| 33784440 | 2021 | Effect and in silico characterization of genetic variants associated with severe spermatogenic disorders in a large Iberian cohort. | 9 |
| 34675326 | 2021 | Gene transfer of MRCKα rescues lipopolysaccharide-induced acute lung injury by restoring alveolar capillary barrier function. | 3 |
| 33476437 | 2021 | Myotonic dystrophy kinase-related CDC42-binding kinase α, a new transferrin receptor type 2-binding partner, is a regulator of erythropoiesis. | 1 |
| 33507884 | 2021 | The Na+, K+-ATPase β1 subunit regulates epithelial tight junctions via MRCKα. | 9 |
| 33784440 | 2021 | Effect and in silico characterization of genetic variants associated with severe spermatogenic disorders in a large Iberian cohort. | 9 |
| 34675326 | 2021 | Gene transfer of MRCKα rescues lipopolysaccharide-induced acute lung injury by restoring alveolar capillary barrier function. | 3 |
| 32071169 | 2020 | Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma. | 15 |
| 32071169 | 2020 | Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma. | 15 |
| 29072916 | 2018 | Comparative Proteomics Analysis Identifies Cdc42-Cdc42BPA Signaling as Prognostic Biomarker and Therapeutic Target for Colon Cancer Invasion. | 10 |
| 29162624 | 2018 | MRCKα is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion. | 15 |
| 29072916 | 2018 | Comparative Proteomics Analysis Identifies Cdc42-Cdc42BPA Signaling as Prognostic Biomarker and Therapeutic Target for Colon Cancer Invasion. | 10 |
Citation
Dessen P
CDC42BPA (CDC42 binding protein kinase alpha)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43197/cdc42bpa-(cdc42-binding-protein-kinase-alpha)
