KDM4C (Gene amplified in squamous cell carcinoma 1)

2002-12-01   Zeng-Quan Yang  

University of Michigan, Department of Radiation Oncology, RM. 7121 CCGC, 1500 E Med Ctr. Dr., Ann Arbor, MI 48109-0948, USA

Identity

HGNC
KDM4C
LOCATION
9p24.1
LOCUSID
23081
ALIAS
GASC1,JHDM3C,JMJD2C,TDRD14C
FUSION GENES
Show Gene Fusions

DNA/RNA

Note

At least 22 exons spanning approximately 417194 bps. 4239 bp mRNA; coding sequence: 3171 bp

Proteins

Description

1056 ammino acid; possesses PHD domain

Implicated in

Entity name
amplification and overexpression in cell lines derived from esophageal squamous cell carcinomas

Article Bibliography

Pubmed IDLast YearTitleAuthors
113464652001A novel amplicon at 9p23 - 24 in squamous cell carcinoma of the esophagus that lies proximal to GASC1 and harbors NFIB.Yang ZQ et al

Other Information

Locus ID:

NCBI: 23081
MIM: 605469
HGNC: 17071
Ensembl: ENSG00000107077

Variants:

dbSNP: 23081
ClinVar: 23081
TCGA: ENSG00000107077
COSMIC: KDM4C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107077ENST00000381306Q9H3R0
ENSG00000107077ENST00000381309Q9H3R0
ENSG00000107077ENST00000401787B0QZ60
ENSG00000107077ENST00000420847A0A0A0MSR6
ENSG00000107077ENST00000428870C9J879
ENSG00000107077ENST00000438023F8WCN1
ENSG00000107077ENST00000536108Q9H3R0
ENSG00000107077ENST00000543771Q9H3R0

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PKNsREACTOMER-HSA-5625740
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3REACTOMER-HSA-5625886
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDMs demethylate histonesREACTOMER-HSA-3214842

References

Pubmed IDYearTitleCitations
382526692024The promotive role of lncRNA MIR205HG in proliferation, invasion, and migration of melanoma cells via the JMJD2C/ALKBH5 axis.0
382526692024The promotive role of lncRNA MIR205HG in proliferation, invasion, and migration of melanoma cells via the JMJD2C/ALKBH5 axis.0
354846532023KDM4C in germinal center lymphoma: a new piece of the epigenetic puzzle.0
355221482023Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas.1
367093542023The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2(V617F) mutated cells.1
378489462023KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations.3
354846532023KDM4C in germinal center lymphoma: a new piece of the epigenetic puzzle.0
355221482023Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas.1
367093542023The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2(V617F) mutated cells.1
378489462023KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations.3
342819932022Novel germline variant in the histone demethylase and transcription regulator KDM4C induces a multi-cancer phenotype.1
350463872022JMJD2C-mediated long non-coding RNA MALAT1/microRNA-503-5p/SEPT2 axis worsens non-small cell lung cancer.5
353430732022Inhibition of KDM4C/c-Myc/LDHA signalling axis suppresses prostate cancer metastasis via interference of glycolytic metabolism.7
354145032022Histone Demethylase GASC1 Inhibitor Targeted GASC1 Gene to Inhibit the Malignant Transformation of Esophageal Cancer through the NOTCH-MAPK Signaling Pathway.1
360125772022Essential Roles of the Histone Demethylase KDM4C in Renal Development and Acute Kidney Injury.3

Citation

Zeng-Quan Yang

KDM4C (Gene amplified in squamous cell carcinoma 1)

Atlas Genet Cytogenet Oncol Haematol. 2002-12-01

Online version: http://atlasgeneticsoncology.org/gene/432/kdm4c-(gene-amplified-in-squamous-cell-carcinoma-1)