KDM4C (Gene amplified in squamous cell carcinoma 1)
2002-12-01 Zeng-Quan Yang AffiliationUniversity of Michigan, Department of Radiation Oncology, RM. 7121 CCGC, 1500 E Med Ctr. Dr., Ann Arbor, MI 48109-0948, USA
Identity
HGNC
LOCATION
9p24.1
LOCUSID
ALIAS
GASC1,JHDM3C,JMJD2C,TDRD14C
FUSION GENES
DNA/RNA
Note
At least 22 exons spanning approximately 417194 bps. 4239 bp mRNA; coding sequence: 3171 bp
Proteins
Description
1056 ammino acid; possesses PHD domain
Implicated in
Entity name
amplification and overexpression in cell lines derived from esophageal squamous cell carcinomas
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 11346465 | 2001 | A novel amplicon at 9p23 - 24 in squamous cell carcinoma of the esophagus that lies proximal to GASC1 and harbors NFIB. | Yang ZQ et al |
Other Information
Locus ID:
NCBI: 23081
MIM: 605469
HGNC: 17071
Ensembl: ENSG00000107077
Variants:
dbSNP: 23081
ClinVar: 23081
TCGA: ENSG00000107077
COSMIC: KDM4C
RNA/Proteins
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38252669 | 2024 | The promotive role of lncRNA MIR205HG in proliferation, invasion, and migration of melanoma cells via the JMJD2C/ALKBH5 axis. | 0 |
| 38252669 | 2024 | The promotive role of lncRNA MIR205HG in proliferation, invasion, and migration of melanoma cells via the JMJD2C/ALKBH5 axis. | 0 |
| 35484653 | 2023 | KDM4C in germinal center lymphoma: a new piece of the epigenetic puzzle. | 0 |
| 35522148 | 2023 | Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas. | 1 |
| 36709354 | 2023 | The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2(V617F) mutated cells. | 1 |
| 37848946 | 2023 | KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations. | 3 |
| 35484653 | 2023 | KDM4C in germinal center lymphoma: a new piece of the epigenetic puzzle. | 0 |
| 35522148 | 2023 | Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas. | 1 |
| 36709354 | 2023 | The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2(V617F) mutated cells. | 1 |
| 37848946 | 2023 | KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations. | 3 |
| 34281993 | 2022 | Novel germline variant in the histone demethylase and transcription regulator KDM4C induces a multi-cancer phenotype. | 1 |
| 35046387 | 2022 | JMJD2C-mediated long non-coding RNA MALAT1/microRNA-503-5p/SEPT2 axis worsens non-small cell lung cancer. | 5 |
| 35343073 | 2022 | Inhibition of KDM4C/c-Myc/LDHA signalling axis suppresses prostate cancer metastasis via interference of glycolytic metabolism. | 7 |
| 35414503 | 2022 | Histone Demethylase GASC1 Inhibitor Targeted GASC1 Gene to Inhibit the Malignant Transformation of Esophageal Cancer through the NOTCH-MAPK Signaling Pathway. | 1 |
| 36012577 | 2022 | Essential Roles of the Histone Demethylase KDM4C in Renal Development and Acute Kidney Injury. | 3 |
Citation
Zeng-Quan Yang
KDM4C (Gene amplified in squamous cell carcinoma 1)
Atlas Genet Cytogenet Oncol Haematol. 2002-12-01
Online version: http://atlasgeneticsoncology.org/gene/432/kdm4c-(gene-amplified-in-squamous-cell-carcinoma-1)
