Identity
HGNC
LOCATION
9q34.11
LOCUSID
ALIAS
C-2k,CDC2L4,CTK1,PITALRE,TAK
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1025
MIM: 603251
HGNC: 1780
Ensembl: ENSG00000136807
Variants:
dbSNP: 1025
ClinVar: 1025
TCGA: ENSG00000136807
COSMIC: CDK9
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000136807 | ENST00000373264 | P50750 |
| ENSG00000136807 | ENST00000373264 | A0A024R880 |
| ENSG00000136807 | ENST00000421939 | X6RE90 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37551745 | 2024 | CDK7 and CDK9 inhibition interferes with transcription, translation, and stemness, and induces cytotoxicity in GBM irrespective of temozolomide sensitivity. | 2 |
| 38301887 | 2024 | Actin associates with actively elongating genes and binds directly to the Cdk9 subunit of P-TEFb. | 0 |
| 38315842 | 2024 | RNF20 contributes to epigenetic immunosuppression through CDK9-dependent LSD1 stabilization. | 1 |
| 38661032 | 2024 | CDK9 inhibition activates innate immune response through viral mimicry. | 1 |
| 38848777 | 2024 | Transcriptional regulation and therapeutic potential of cyclin-dependent kinase 9 (CDK9) in sarcoma. | 0 |
| 37551745 | 2024 | CDK7 and CDK9 inhibition interferes with transcription, translation, and stemness, and induces cytotoxicity in GBM irrespective of temozolomide sensitivity. | 2 |
| 38301887 | 2024 | Actin associates with actively elongating genes and binds directly to the Cdk9 subunit of P-TEFb. | 0 |
| 38315842 | 2024 | RNF20 contributes to epigenetic immunosuppression through CDK9-dependent LSD1 stabilization. | 1 |
| 38661032 | 2024 | CDK9 inhibition activates innate immune response through viral mimicry. | 1 |
| 38848777 | 2024 | Transcriptional regulation and therapeutic potential of cyclin-dependent kinase 9 (CDK9) in sarcoma. | 0 |
| 36896891 | 2023 | Histone-lysine N-methyltransferase EHMT2 (G9a) inhibition mitigates tumorigenicity in Myc-driven liver cancer. | 5 |
| 37060507 | 2023 | Selective CDK9 knockdown sensitizes TRAIL response by suppression of antiapoptotic factors and NF-kappaB pathway. | 1 |
| 37564002 | 2023 | Degradation of CDK9 by Ubiquitin E3 Ligase STUB1 Regulates P-TEFb Level and Its Functions for Global Target Gene Expression within Mammalian Cells. | 0 |
| 36896891 | 2023 | Histone-lysine N-methyltransferase EHMT2 (G9a) inhibition mitigates tumorigenicity in Myc-driven liver cancer. | 5 |
| 37060507 | 2023 | Selective CDK9 knockdown sensitizes TRAIL response by suppression of antiapoptotic factors and NF-kappaB pathway. | 1 |
Citation
Dessen P
CDK9 (cyclin dependent kinase 9)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43202/cdk9
