CIT (citron rho-interacting serine/threonine kinase)

2006-10-01  

Identity

HGNC
LOCATION
12q24.23
LOCUSID
ALIAS
CITK,CRIK,MCPH17,STK21
FUSION GENES

Other Information

Locus ID:

NCBI: 11113
MIM: 605629
HGNC: 1985
Ensembl: ENSG00000122966

Variants:

dbSNP: 11113
ClinVar: 11113
TCGA: ENSG00000122966
COSMIC: CIT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122966ENST00000261833O14578
ENSG00000122966ENST00000392520H7BYJ3
ENSG00000122966ENST00000392521O14578
ENSG00000122966ENST00000536325H0YGG8
ENSG00000122966ENST00000546026F5H4K4
ENSG00000122966ENST00000612548O14578

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate CITREACTOMER-HSA-5625900

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
164319292006KIF14 and citron kinase act together to promote efficient cytokinesis.99
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
218494732011Citron kinase controls abscission through RhoA and anillin.50
200845192010Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging.41
200845192010Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging.41
175341522007ASPM and citron kinase co-localize to the midbody ring during cytokinesis.35
227617152012Identification of kinases regulating prostate cancer cell growth using an RNAi phenotypic screen.27
274535782016Biallelic Mutations in Citron Kinase Link Mitotic Cytokinesis to Human Primary Microcephaly.23
274535792016Mutations in Citron Kinase Cause Recessive Microlissencephaly with Multinucleated Neurons.21

Citation

Dessen P

CIT (citron rho-interacting serine/threonine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43214/cit-(citron-rho-interacting-serine-threonine-kinase)