CSNK2A1 (casein kinase 2 alpha 1)

2006-10-01  

Identity

HGNC
LOCATION
20p13
LOCUSID
ALIAS
CK2A1,CKII,Cka1,Cka2,OCNDS
FUSION GENES

Other Information

Locus ID:

NCBI: 1457
MIM: 115440
HGNC: 2457
Ensembl: ENSG00000101266

Variants:

dbSNP: 1457
ClinVar: 1457
TCGA: ENSG00000101266
COSMIC: CSNK2A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101266ENST00000217244P68400
ENSG00000101266ENST00000349736P68400
ENSG00000101266ENST00000400217P68400
ENSG00000101266ENST00000400227E7EU96
ENSG00000101266ENST00000460062V9GYW6
ENSG00000101266ENST00000608066V9GY80
ENSG00000101266ENST00000609525V9GYA2
ENSG00000101266ENST00000619801A0A087WY74
ENSG00000101266ENST00000642160A0A2R8Y797
ENSG00000101266ENST00000642689A0A2R8YFU2
ENSG00000101266ENST00000643600A0A2R8Y4H0
ENSG00000101266ENST00000643660P68400
ENSG00000101266ENST00000643680A0A2R8Y4D6
ENSG00000101266ENST00000643910A0A2R8YCC9
ENSG00000101266ENST00000643968A0A2R8YCK2
ENSG00000101266ENST00000644003P68400
ENSG00000101266ENST00000644177A0A2R8YDY7
ENSG00000101266ENST00000644710A0A2R8YFU2
ENSG00000101266ENST00000644885A0A2R8YF43
ENSG00000101266ENST00000645091A0A2R8YEW1
ENSG00000101266ENST00000645187A0A2R8Y7T1
ENSG00000101266ENST00000645234A0A2R8YD58
ENSG00000101266ENST00000645249A0A2R8YF47
ENSG00000101266ENST00000645260A0A2R8YDP2
ENSG00000101266ENST00000645623P68400
ENSG00000101266ENST00000645840A0A2R8YEL7
ENSG00000101266ENST00000645910A0A2R8YCK2
ENSG00000101266ENST00000646305P68400
ENSG00000101266ENST00000646477P68400
ENSG00000101266ENST00000646561P68400
ENSG00000101266ENST00000646814P68400
ENSG00000101266ENST00000646908A0A2R8Y3W6
ENSG00000101266ENST00000647026A0A2R8Y5A0
ENSG00000101266ENST00000647348P68400

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Adherens junctionKEGGko04520
Wnt signaling pathwayKEGGhsa04310
Adherens junctionKEGGhsa04520
Ribosome biogenesis in eukaryotesKEGGko03008
Ribosome biogenesis in eukaryotesKEGGhsa03008
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
WNT mediated activation of DVLREACTOMER-HSA-201688
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Condensation of Prometaphase ChromosomesREACTOMER-HSA-2514853
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Synthesis of PCREACTOMER-HSA-1483191
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
Signal transduction by L1REACTOMER-HSA-445144
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingREACTOMER-HSA-6814122
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
233175042013Phospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targeting.119
199418162009EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin.118
158184042005Protein kinase CK2 phosphorylates and upregulates Akt/PKB.105
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
161073422005Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta.76
223179212012Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7.75
208640322010CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.73
126289232003Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome.61
191655272009Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.56
237329142013PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2.55

Citation

Dessen P

CSNK2A1 (casein kinase 2 alpha 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43221/csnk2a1-(casein-kinase-2-alpha-1)