PREX2 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2)
2006-10-01 AffiliationIdentity
HGNC
LOCATION
8q13.2
LOCUSID
ALIAS
DEP.2,DEPDC2,P-REX2,PPP1R129
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 80243
MIM: 612139
HGNC: 22950
Ensembl: ENSG00000046889
Variants:
dbSNP: 80243
ClinVar: 80243
TCGA: ENSG00000046889
COSMIC: PREX2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000046889 | ENST00000288368 | Q70Z35 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33947796 | 2021 | Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1. | 3 |
| 34322848 | 2021 | Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 2 Protein Facilitates Glioma Progression via Akt and Stat3 Signaling. | 2 |
| 34705970 | 2021 | PREX2 gene's expression in gastric antral epithelial cells of patients with H. pylori infection. | 1 |
| 33947796 | 2021 | Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1. | 3 |
| 34322848 | 2021 | Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 2 Protein Facilitates Glioma Progression via Akt and Stat3 Signaling. | 2 |
| 34705970 | 2021 | PREX2 gene's expression in gastric antral epithelial cells of patients with H. pylori infection. | 1 |
| 31241130 | 2020 | CELF2 suppresses non-small cell lung carcinoma growth by inhibiting the PREX2-PTEN interaction. | 24 |
| 31711559 | 2020 | MicroRNA-561 Affects Proliferation and Cell Cycle Transition Through PTEN/AKT Signaling Pathway by Targeting P-REX2a in NSCLC. | 8 |
| 31241130 | 2020 | CELF2 suppresses non-small cell lung carcinoma growth by inhibiting the PREX2-PTEN interaction. | 24 |
| 31711559 | 2020 | MicroRNA-561 Affects Proliferation and Cell Cycle Transition Through PTEN/AKT Signaling Pathway by Targeting P-REX2a in NSCLC. | 8 |
| 30796242 | 2019 | Somatic mutations of PREX2 gene in patients with hepatocellular carcinoma. | 13 |
| 30796242 | 2019 | Somatic mutations of PREX2 gene in patients with hepatocellular carcinoma. | 13 |
| 30213289 | 2018 | MiR-637 suppresses melanoma progression through directly targeting P-REX2a and inhibiting PTEN/AKT signaling pathway. | 13 |
| 30213289 | 2018 | MiR-637 suppresses melanoma progression through directly targeting P-REX2a and inhibiting PTEN/AKT signaling pathway. | 13 |
| 28100393 | 2017 | Melanoma mystery. | 2 |
Citation
Dessen P
PREX2 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43227/prex2-(phosphatidylinositol-3-4-5-trisphosphate-dependent-rac-exchange-factor-2)
