DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2)

2006-10-01  

Identity

HGNC
DYRK2
LOCATION
12q15
LOCUSID
8445
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8445
MIM: 603496
HGNC: 3093
Ensembl: ENSG00000127334

Variants:

dbSNP: 8445
ClinVar: 8445
TCGA: ENSG00000127334
COSMIC: DYRK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127334ENST00000319833A0A0A0MR56
ENSG00000127334ENST00000344096Q92630
ENSG00000127334ENST00000393555Q92630
ENSG00000127334ENST00000542503F5H5L5
ENSG00000127334ENST00000543747F5GXG1

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385082852024Dual-specificity tyrosine-regulated kinase 2 exerts anti-tumor effects by induction of G1 arrest in lung adenocarcinoma.0
385082852024Dual-specificity tyrosine-regulated kinase 2 exerts anti-tumor effects by induction of G1 arrest in lung adenocarcinoma.0
366223662023Dual inhibition of HSF1 and DYRK2 impedes cancer progression.2
369341042023FBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2.5
366223662023Dual inhibition of HSF1 and DYRK2 impedes cancer progression.2
369341042023FBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2.5
353470312022Combination of DYRK2 and TERT Expression Is a Powerful Predictive Marker for Early-stage Breast Cancer Recurrence.2
354391142022Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry.5
353470312022Combination of DYRK2 and TERT Expression Is a Powerful Predictive Marker for Early-stage Breast Cancer Recurrence.2
354391142022Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry.5
333681382021Frequent DYRK2 gene amplification in micropapillary element of lung adenocarcinoma - an implication in progression in EGFR-mutated lung adenocarcinoma.3
333761362021Emerging roles of DYRK2 in cancer.27
333681382021Frequent DYRK2 gene amplification in micropapillary element of lung adenocarcinoma - an implication in progression in EGFR-mutated lung adenocarcinoma.3
333761362021Emerging roles of DYRK2 in cancer.27
322366212020Impairment of DYRK2 by DNMT1‑mediated transcription augments carcinogenesis in human colorectal cancer.9

Citation

Dessen P

DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43236/dyrk2-(dual-specificity-tyrosine-phosphorylation-regulated-kinase-2)