Identity
HGNC
LOCATION
15q15.1
LOCUSID
ALIAS
GCN2,PVOD2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 440275
MIM: 609280
HGNC: 19687
Ensembl: ENSG00000128829
Variants:
dbSNP: 440275
ClinVar: 440275
TCGA: ENSG00000128829
COSMIC: EIF2AK4
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | 24751813 | |
| PA449841 | haloperidol | Chemical | ClinicalAnnotation, MultilinkAnnotation | associated | PD | 24751813, 27023437 | |
| PA450688 | olanzapine | Chemical | ClinicalAnnotation | associated | PD | 24751813 | |
| PA451201 | quetiapine | Chemical | ClinicalAnnotation | associated | PD | 24751813 | |
| PA451257 | risperidone | Chemical | ClinicalAnnotation | associated | PD | 24751813 | |
| PA451974 | ziprasidone | Chemical | ClinicalAnnotation | associated | PD | 24751813 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38175755 | 2024 | Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes. | 2 |
| 38281137 | 2024 | Multiple mechanisms activate GCN2 eIF2 kinase in response to diverse stress conditions. | 1 |
| 38175755 | 2024 | Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes. | 2 |
| 38281137 | 2024 | Multiple mechanisms activate GCN2 eIF2 kinase in response to diverse stress conditions. | 1 |
| 36476191 | 2023 | Disruption of GCN2 Pathway Aggravates Vascular and Parenchymal Remodeling during Pulmonary Fibrosis. | 4 |
| 36633383 | 2023 | A new mutation in the EIF2AK4 gene in familial pulmonary veno-occlusive disease. | 1 |
| 36901714 | 2023 | Multiple Roles of the Stress Sensor GCN2 in Immune Cells. | 5 |
| 37017529 | 2023 | Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction. | 1 |
| 37199644 | 2023 | Hepatitis E Virus Protease Inhibits the Activity of Eukaryotic Initiation Factor 2-Alpha Kinase 4 and Promotes Virus Survival. | 0 |
| 36476191 | 2023 | Disruption of GCN2 Pathway Aggravates Vascular and Parenchymal Remodeling during Pulmonary Fibrosis. | 4 |
| 36633383 | 2023 | A new mutation in the EIF2AK4 gene in familial pulmonary veno-occlusive disease. | 1 |
| 36901714 | 2023 | Multiple Roles of the Stress Sensor GCN2 in Immune Cells. | 5 |
| 37017529 | 2023 | Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction. | 1 |
| 37199644 | 2023 | Hepatitis E Virus Protease Inhibits the Activity of Eukaryotic Initiation Factor 2-Alpha Kinase 4 and Promotes Virus Survival. | 0 |
| 35137449 | 2022 | Amino acid restriction induces a long non-coding RNA UBA6-AS1 to regulate GCN2-mediated integrated stress response in breast cancer. | 6 |
Citation
Dessen P
EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43241/eif2ak4-(eukaryotic-translation-initiation-factor-2-alpha-kinase-4)
