EPHB1 (EPH receptor B1)

2006-10-01 Affiliation

Identity

HGNC

EPHB1

LOCATION

3q22.2

LOCUSID

2047

ALIAS

ELK,EPHT2,Hek6,NET

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2047
MIM: 600600
HGNC: 3392
Ensembl: ENSG00000154928

Variants:

dbSNP: 2047
ClinVar: 2047
TCGA: ENSG00000154928
COSMIC: EPHB1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000154928	ENST00000398015	P54762
ENSG00000154928	ENST00000460895	C9JB88
ENSG00000154928	ENST00000473867	C9J466
ENSG00000154928	ENST00000474732	C9J6S4
ENSG00000154928	ENST00000482618	F8WDG5
ENSG00000154928	ENST00000493838	P54762
ENSG00000154928	ENST00000497173	C9K090
ENSG00000154928	ENST00000647596	A0A3B3IRY8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Axon guidance	KEGG	ko04360
Axon guidance	KEGG	hsa04360
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
EPH-Ephrin signaling	REACTOME	R-HSA-2682334
EPHB-mediated forward signaling	REACTOME	R-HSA-3928662
Ephrin signaling	REACTOME	R-HSA-3928664
EPH-ephrin mediated repulsion of cells	REACTOME	R-HSA-3928665

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19736353	2009	A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression.	94
21804545	2011	Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling.	66
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
15722342	2005	EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity.	57
18057206	2007	EphB receptors regulate stem/progenitor cell proliferation, migration, and polarity during hippocampal neurogenesis.	55
21041834	2012	Resequencing and association analysis of the KALRN and EPHB1 genes and their contribution to schizophrenia susceptibility.	40
21041834	2012	Resequencing and association analysis of the KALRN and EPHB1 genes and their contribution to schizophrenia susceptibility.	40
12084815	2002	Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred.	34
14576067	2004	Signaling by ephrinB1 and Eph kinases in platelets promotes Rap1 activation, platelet adhesion, and aggregation via effector pathways that do not require phosphorylation of ephrinB1.	21
11140838	2000	A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory.	20

Citation

Dessen P

EPHB1 (EPH receptor B1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43245/ephb1-(eph-receptor-b1)