EPHB1 (EPH receptor B1)

2006-10-01  

Identity

HGNC
LOCATION
3q22.2
LOCUSID
ALIAS
ELK,EPHT2,Hek6,NET
FUSION GENES

Other Information

Locus ID:

NCBI: 2047
MIM: 600600
HGNC: 3392
Ensembl: ENSG00000154928

Variants:

dbSNP: 2047
ClinVar: 2047
TCGA: ENSG00000154928
COSMIC: EPHB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154928ENST00000398015P54762
ENSG00000154928ENST00000460895C9JB88
ENSG00000154928ENST00000473867C9J466
ENSG00000154928ENST00000474732C9J6S4
ENSG00000154928ENST00000482618F8WDG5
ENSG00000154928ENST00000493838P54762
ENSG00000154928ENST00000497173C9K090
ENSG00000154928ENST00000647596A0A3B3IRY8

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHB-mediated forward signalingREACTOMER-HSA-3928662
Ephrin signalingREACTOMER-HSA-3928664
EPH-ephrin mediated repulsion of cellsREACTOMER-HSA-3928665

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
197363532009A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression.94
218045452011Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling.66
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
157223422005EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity.57
180572062007EphB receptors regulate stem/progenitor cell proliferation, migration, and polarity during hippocampal neurogenesis.55
210418342012Resequencing and association analysis of the KALRN and EPHB1 genes and their contribution to schizophrenia susceptibility.40
210418342012Resequencing and association analysis of the KALRN and EPHB1 genes and their contribution to schizophrenia susceptibility.40
120848152002Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred.34
145760672004Signaling by ephrinB1 and Eph kinases in platelets promotes Rap1 activation, platelet adhesion, and aggregation via effector pathways that do not require phosphorylation of ephrinB1.21
111408382000A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory.20

Citation

Dessen P

EPHB1 (EPH receptor B1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43245/ephb1-(eph-receptor-b1)