EPHB1 (EPH receptor B1)

2006-10-01  

Identity

HGNC
EPHB1
LOCATION
3q22.2
LOCUSID
2047
ALIAS
ELK,EPHT2,Hek6,NET
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2047
MIM: 600600
HGNC: 3392
Ensembl: ENSG00000154928

Variants:

dbSNP: 2047
ClinVar: 2047
TCGA: ENSG00000154928
COSMIC: EPHB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154928ENST00000398015P54762
ENSG00000154928ENST00000460895C9JB88
ENSG00000154928ENST00000473867C9J466
ENSG00000154928ENST00000474732C9J6S4
ENSG00000154928ENST00000482618F8WDG5
ENSG00000154928ENST00000493838P54762
ENSG00000154928ENST00000497173C9K090
ENSG00000154928ENST00000647596A0A3B3IRY8

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHB-mediated forward signalingREACTOMER-HSA-3928662
Ephrin signalingREACTOMER-HSA-3928664
EPH-ephrin mediated repulsion of cellsREACTOMER-HSA-3928665

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381027122023Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells.0
381027122023Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells.0
336274802021Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain.5
336274802021Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain.5
333568372020Peripheral EphrinB1/EphB1 signalling attenuates muscle hyperalgesia in MPS patients and a rat model of taut band-associated persistent muscle pain.2
333568372020Peripheral EphrinB1/EphB1 signalling attenuates muscle hyperalgesia in MPS patients and a rat model of taut band-associated persistent muscle pain.2
304017462019Regulation of Connexin32 by ephrin receptors and T-cell protein-tyrosine phosphatase.3
304017462019Regulation of Connexin32 by ephrin receptors and T-cell protein-tyrosine phosphatase.3
295508162018Sumoylation of EphB1 Suppresses Neuroblastoma Tumorigenesis via Inhibiting PKCγ Activation.1
295508162018Sumoylation of EphB1 Suppresses Neuroblastoma Tumorigenesis via Inhibiting PKCγ Activation.1
281085142017Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer.20
281085142017Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer.20
270285442016Association of EPHB1 rs11918092 and EFNB2 rs9520087 with psychopathological symptoms of schizophrenia in Chinese Zhuang and Han populations.4
275417942016Investigating the genetic basis of attention to facial expressions: the role of the norepinephrine transporter gene.3
270285442016Association of EPHB1 rs11918092 and EFNB2 rs9520087 with psychopathological symptoms of schizophrenia in Chinese Zhuang and Han populations.4

Citation

Dessen P

EPHB1 (EPH receptor B1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43245/ephb1-(eph-receptor-b1)