ERN1 (endoplasmic reticulum to nucleus signaling 1)

2006-10-01   Dessen P  

Identity

HGNC
ERN1
LOCATION
17q23.3
LOCUSID
2081
ALIAS
IRE1,IRE1P,IRE1a,hIRE1p
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2081
MIM: 604033
HGNC: 3449
Ensembl: ENSG00000178607

Variants:

dbSNP: 2081
ClinVar: 2081
TCGA: ENSG00000178607
COSMIC: ERN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178607ENST00000433197O75460
ENSG00000178607ENST00000606895O75460

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
ApoptosisKEGGko04210
Alzheimer's diseaseKEGGko05010
Autophagy - animalKEGGhsa04140
ApoptosisKEGGhsa04210
Alzheimer's diseaseKEGGhsa05010
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380718012024Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown.1
381460012024Innate IRE1α-XBP1 activation by viral single-stranded RNA and its influence on lung cytokine production during SARS-CoV-2 pneumonia.0
385632932024ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells.0
385782852024IRE1α recognizes a structural motif in cholera toxin to activate an unfolded protein response.0
386489022024The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection.0
386562542024Inhibition of signaling protein ERN1 increases the sensitivity of serine synthesis gene expressions to glucose and glutamine deprivations in U87MG glioblastoma cells.0
387272832024TurboID-Based IRE1 Interactome Reveals Participants of the Endoplasmic Reticulum-Associated Protein Degradation Machinery in the Human Mast Cell Leukemia Cell Line HMC-1.2.0
380718012024Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown.1
381460012024Innate IRE1α-XBP1 activation by viral single-stranded RNA and its influence on lung cytokine production during SARS-CoV-2 pneumonia.0
385632932024ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells.0
385782852024IRE1α recognizes a structural motif in cholera toxin to activate an unfolded protein response.0
386489022024The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection.0
386562542024Inhibition of signaling protein ERN1 increases the sensitivity of serine synthesis gene expressions to glucose and glutamine deprivations in U87MG glioblastoma cells.0
387272832024TurboID-Based IRE1 Interactome Reveals Participants of the Endoplasmic Reticulum-Associated Protein Degradation Machinery in the Human Mast Cell Leukemia Cell Line HMC-1.2.0
366240932023Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer.7

Citation

Dessen P

ERN1 (endoplasmic reticulum to nucleus signaling 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43247/ern1-(endoplasmic-reticulum-to-nucleus-signaling-1)