FCHSD2 (FCH and double SH3 domains 2)

2006-10-01  

Identity

HGNC
FCHSD2
LOCATION
11q13.4
LOCUSID
9873
ALIAS
NWK,NWK1,SH3MD3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9873
MIM: 617556
HGNC: 29114
Ensembl: ENSG00000137478

Variants:

dbSNP: 9873
ClinVar: 9873
TCGA: ENSG00000137478
COSMIC: FCHSD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137478ENST00000311172O94868
ENSG00000137478ENST00000311172A0A024R5H2
ENSG00000137478ENST00000409263B8ZZW8
ENSG00000137478ENST00000409314E9PG19
ENSG00000137478ENST00000409418O94868
ENSG00000137478ENST00000409853O94868
ENSG00000137478ENST00000422375C9JM66
ENSG00000137478ENST00000432043H0Y6M2
ENSG00000137478ENST00000458644E7ENZ2
ENSG00000137478ENST00000543644H0YG35

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
345208162022FCHSD2 cooperates with CDC42 and N-WASP to regulate cell protrusion formation.2
345208162022FCHSD2 cooperates with CDC42 and N-WASP to regulate cell protrusion formation.2
326788452020FCHSD2 controls oncogenic ERK1/2 signaling outcome by regulating endocytic trafficking.12
326788452020FCHSD2 controls oncogenic ERK1/2 signaling outcome by regulating endocytic trafficking.12
302496602018Role for ERK1/2-dependent activation of FCHSD2 in cancer cell-selective regulation of clathrin-mediated endocytosis.20
302496602018Role for ERK1/2-dependent activation of FCHSD2 in cancer cell-selective regulation of clathrin-mediated endocytosis.20
281992112017Endocytosis and membrane receptor internalization: implication of F-BAR protein Carom.15
281992112017Endocytosis and membrane receptor internalization: implication of F-BAR protein Carom.15
266633012016Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.39
266633012016Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.39
229020562012FCHSD2 predicts response to chemotherapy in acute myeloid leukemia patients.7
229020562012FCHSD2 predicts response to chemotherapy in acute myeloid leukemia patients.7
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

FCHSD2 (FCH and double SH3 domains 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43258/fchsd2-(fch-and-double-sh3-domains-2)