Identity
HGNC
LOCATION
12p11.21
LOCUSID
ALIAS
CMT4H,FRABP,ZFYVE6
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 121512
MIM: 611104
HGNC: 19125
Ensembl: ENSG00000139132
Variants:
dbSNP: 121512
ClinVar: 121512
TCGA: ENSG00000139132
COSMIC: FGD4
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA450761 | paclitaxel | Chemical | ClinicalAnnotation | associated | PD | 22843789 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33709789 | 2021 | Polymorphism of FGD4 and myelosuppression in patients with esophageal squamous cell carcinoma. | 2 |
| 33709789 | 2021 | Polymorphism of FGD4 and myelosuppression in patients with esophageal squamous cell carcinoma. | 2 |
| 31852984 | 2020 | Identification of novel pathogenic copy number variations in Charcot-Marie-Tooth disease. | 4 |
| 32633323 | 2020 | Circular RNA circFGD4 suppresses gastric cancer progression via modulating miR-532-3p/APC/β-catenin signalling pathway. | 11 |
| 32772928 | 2020 | MiR-23a induced the activation of CDC42/PAK1 pathway and cell cycle arrest in human cov434 cells by targeting FGD4. | 3 |
| 31852984 | 2020 | Identification of novel pathogenic copy number variations in Charcot-Marie-Tooth disease. | 4 |
| 32633323 | 2020 | Circular RNA circFGD4 suppresses gastric cancer progression via modulating miR-532-3p/APC/β-catenin signalling pathway. | 11 |
| 32772928 | 2020 | MiR-23a induced the activation of CDC42/PAK1 pathway and cell cycle arrest in human cov434 cells by targeting FGD4. | 3 |
| 30558664 | 2018 | Expression of FGD4 positively correlates with the aggressive phenotype of prostate cancer. | 7 |
| 30558664 | 2018 | Expression of FGD4 positively correlates with the aggressive phenotype of prostate cancer. | 7 |
| 27736846 | 2016 | Genotypes of CYP2C8 and FGD4 and their association with peripheral neuropathy or early dose reduction in paclitaxel-treated breast cancer patients. | 18 |
| 27736846 | 2016 | Genotypes of CYP2C8 and FGD4 and their association with peripheral neuropathy or early dose reduction in paclitaxel-treated breast cancer patients. | 18 |
| 26400421 | 2015 | Charcot-Marie-Tooth Disease Type 4H Resulting from Compound Heterozygous Mutations in FGD4 from Nonconsanguineous Korean Families. | 3 |
| 26400421 | 2015 | Charcot-Marie-Tooth Disease Type 4H Resulting from Compound Heterozygous Mutations in FGD4 from Nonconsanguineous Korean Families. | 3 |
| 23550889 | 2013 | A novel mutation in FGD4/FRABIN causes Charcot Marie Tooth disease type 4H in patients from a consanguineous Tunisian family. | 7 |
Citation
Dessen P
FGD4 (FYVE, RhoGEF and PH domain containing 4)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43262/fgd4-(fyve-rhogef-and-ph-domain-containing-4)
