GMNN (geminin DNA replication inhibitor)

2006-10-01 Affiliation

Identity

HGNC

GMNN

LOCATION

6p22.3

LOCUSID

51053

ALIAS

Gem,MGORS6

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 51053
MIM: 602842
HGNC: 17493
Ensembl: ENSG00000112312

Variants:

dbSNP: 51053
ClinVar: 51053
TCGA: ENSG00000112312
COSMIC: GMNN

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000112312	ENST00000230056	O75496
ENSG00000112312	ENST00000230056	A0A024QZY7
ENSG00000112312	ENST00000356509	O75496
ENSG00000112312	ENST00000356509	A0A024QZY7
ENSG00000112312	ENST00000378054	E2QRF9
ENSG00000112312	ENST00000378059	H7C608
ENSG00000112312	ENST00000476555	C9K0U5
ENSG00000112312	ENST00000620958	O75496
ENSG00000112312	ENST00000620958	A0A024QZY7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
Regulation of DNA replication	REACTOME	R-HSA-69304
Association of licensing factors with the pre-replicative complex	REACTOME	R-HSA-69298
Removal of licensing factors from origins	REACTOME	R-HSA-69300
M/G1 Transition	REACTOME	R-HSA-68874
DNA Replication Pre-Initiation	REACTOME	R-HSA-69002
Assembly of the pre-replicative complex	REACTOME	R-HSA-68867
CDT1 association with the CDC6:ORC:origin complex	REACTOME	R-HSA-68827
DNA Replication	REACTOME	R-HSA-69306

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15282313	2004	Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint.	116
15159417	2004	Loss of Geminin induces rereplication in the presence of functional p53.	110
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
15257290	2004	Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis.	71
14993212	2004	Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding.	70
19487297	2009	Selective killing of cancer cells by suppression of geminin activity.	48
16924111	2006	A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells.	36
15291814	2004	Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines.	35
19906994	2009	Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing.	35
12551974	2003	Human cytomegalovirus infection leads to accumulation of geminin and inhibition of the licensing of cellular DNA replication.	32

Citation

Dessen P

GMNN (geminin DNA replication inhibitor)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43271/gmnn-(geminin-dna-replication-inhibitor)