GMNN (geminin DNA replication inhibitor)

2006-10-01  

Identity

HGNC
LOCATION
6p22.3
LOCUSID
ALIAS
Gem,MGORS6
FUSION GENES

Other Information

Locus ID:

NCBI: 51053
MIM: 602842
HGNC: 17493
Ensembl: ENSG00000112312

Variants:

dbSNP: 51053
ClinVar: 51053
TCGA: ENSG00000112312
COSMIC: GMNN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112312ENST00000230056O75496
ENSG00000112312ENST00000230056A0A024QZY7
ENSG00000112312ENST00000356509O75496
ENSG00000112312ENST00000356509A0A024QZY7
ENSG00000112312ENST00000378054E2QRF9
ENSG00000112312ENST00000378059H7C608
ENSG00000112312ENST00000476555C9K0U5
ENSG00000112312ENST00000620958O75496
ENSG00000112312ENST00000620958A0A024QZY7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Regulation of DNA replicationREACTOMER-HSA-69304
Association of licensing factors with the pre-replicative complexREACTOMER-HSA-69298
Removal of licensing factors from originsREACTOMER-HSA-69300
M/G1 TransitionREACTOMER-HSA-68874
DNA Replication Pre-InitiationREACTOMER-HSA-69002
Assembly of the pre-replicative complexREACTOMER-HSA-68867
CDT1 association with the CDC6:ORC:origin complexREACTOMER-HSA-68827
DNA ReplicationREACTOMER-HSA-69306

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
368077482023RAD51/geminin/γH2AX immunohistochemical expression predicts platinum-based chemotherapy response in ovarian high-grade serous carcinoma.1
369457592023Alterations in the spatiotemporal expression pattern of geminin during human epidermal morphogenesis.0
368077482023RAD51/geminin/γH2AX immunohistochemical expression predicts platinum-based chemotherapy response in ovarian high-grade serous carcinoma.1
369457592023Alterations in the spatiotemporal expression pattern of geminin during human epidermal morphogenesis.0
329728652022Cell kinetic markers in cutaneous squamous and basal cell carcinoma of the head and neck.3
365398492022High expression of GMNN predicts malignant progression and poor prognosis in ACC.1
329728652022Cell kinetic markers in cutaneous squamous and basal cell carcinoma of the head and neck.3
365398492022High expression of GMNN predicts malignant progression and poor prognosis in ACC.1
345991682021SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition.10
348742262021Prognostic value of HPV 16/18 genotyping and geminin mRNA quantification in low-grade cervical squamous intraepithelial lesion.2
345991682021SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition.10
348742262021Prognostic value of HPV 16/18 genotyping and geminin mRNA quantification in low-grade cervical squamous intraepithelial lesion.2
307100642019Overexpression of UHRF1 promoted the proliferation of vascular smooth cells via the regulation of Geminin protein levels.1
316591132019DNA Replication Inhibitor Geminin and Retinoic Acid Signaling Participate in Complex Interactions Associated With Pluripotency.5
318441582019Targeting AXL and RAGE to prevent geminin overexpression-induced triple-negative breast cancer metastasis.7

Citation

Dessen P

GMNN (geminin DNA replication inhibitor)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43271/gmnn-(geminin-dna-replication-inhibitor)