GNAI1 (G protein subunit alpha i1)

Identity

HGNC

GNAI1

LOCATION

7q21.11

LOCUSID

2770

ALIAS

Gi

FUSION GENES

Show Gene Fusions

Other Information

Locus ID:

NCBI: 2770
MIM: 139310
HGNC: 4384
Ensembl: ENSG00000127955

Variants:

dbSNP: 2770
ClinVar: 2770
TCGA: ENSG00000127955
COSMIC: GNAI1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000127955	ENST00000351004	P63096
ENSG00000127955	ENST00000442586	P63096
ENSG00000127955	ENST00000457358	P63096
ENSG00000127955	ENST00000647672	A0A3B3ITM0
ENSG00000127955	ENST00000647742	A0A3B3ITX3
ENSG00000127955	ENST00000648098	P63096
ENSG00000127955	ENST00000648306	P63096
ENSG00000127955	ENST00000648375	A0A3B3IU77
ENSG00000127955	ENST00000648412	P63096
ENSG00000127955	ENST00000648476	P63096

Previous1 2 3Next

Expression (GTEx)

0

10

20

30

40

50

60

70

80

90

100

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Activation of GABAB receptors	REACTOME	R-HSA-991365
Adenylate cyclase inhibitory pathway	REACTOME	R-HSA-170670
ADP signalling through P2Y purinoceptor 12	REACTOME	R-HSA-392170
Adrenaline,noradrenaline inhibits insulin secretion	REACTOME	R-HSA-400042
Adrenergic signaling in cardiomyocytes	KEGG	hsa04261
Adrenergic signaling in cardiomyocytes	KEGG	ko04261
Alcoholism	KEGG	hsa05034
Alcoholism	KEGG	ko05034
Apelin signaling pathway	KEGG	hsa04371
Axon guidance	KEGG	ko04360

Previous1 2 3 4 5…10Next

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA134971947	P2RY12	Gene	Pathway	associated	20938371
PA164741137	ADCY3	Gene	Pathway	associated	20938371
PA192	HTR1A	Gene	Pathway	associated	19741567
PA24560	ADCY1	Gene	Pathway	associated	19741567
PA24561	ADCY2	Gene	Pathway	associated	19741567
PA24562	ADCY4	Gene	Pathway	associated
PA24563	ADCY5	Gene	Pathway	associated
PA27	ADCY6	Gene	Pathway	associated
PA28	ADCY7	Gene	Pathway	associated
PA29	ADCY8	Gene	Pathway	associated

Previous1 2Next

References

Pubmed ID	Year	Title	Citations
31936673	2020	Preferential Coupling of Dopamine D(2S) and D(2L) Receptor Isoforms with G(i1) and G(i2) Proteins-In Silico Study.	10
32126208	2020	Structures of Gα Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms.	13
32193322	2020	Structural basis of G(s) and G(i) recognition by the human glucagon receptor.	73
33493164	2021	Gαi1 inhibition mechanism of ATP-bound adenylyl cyclase type 5.	4
33493164	2021	Gαi1 inhibition mechanism of ATP-bound adenylyl cyclase type 5.	4
33785921	2021	Feeling at home: Structure of the NTSR1-G(i) complex in a lipid environment.	0
33785921	2021	Feeling at home: Structure of the NTSR1-G(i) complex in a lipid environment.	0
33958720	2021	LncRNA PINK1-AS promotes Gαi1-driven gastric cancer tumorigenesis by sponging microRNA-200a.	20
33958720	2021	LncRNA PINK1-AS promotes Gαi1-driven gastric cancer tumorigenesis by sponging microRNA-200a.	20
34860335	2023	Candidate Gene of NOS3, MMP3, AGT, and AGT1R and Pathway Analyses for Platelet Reactivity and Clinical Outcomes of Repeat Revascularization After First PCI in Chinese Patients.	0

Previous1 2Next

Citation

Dessen P

GNAI1 (G protein subunit alpha i1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43276/gnai1-(g-protein-subunit-alpha-i1)