Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2773
MIM: 139370
HGNC: 4387
Ensembl: ENSG00000065135
Variants:
dbSNP: 2773
ClinVar: 2773
TCGA: ENSG00000065135
COSMIC: GNAI3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000065135 | ENST00000369851 | P08754 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA134971947 | P2RY12 | Gene | Pathway | associated | 20938371 | ||
| PA164741137 | ADCY3 | Gene | Pathway | associated | 20938371 | ||
| PA192 | HTR1A | Gene | Pathway | associated | 19741567 | ||
| PA24560 | ADCY1 | Gene | Pathway | associated | 19741567 | ||
| PA24561 | ADCY2 | Gene | Pathway | associated | 19741567 | ||
| PA24562 | ADCY4 | Gene | Pathway | associated | |||
| PA24563 | ADCY5 | Gene | Pathway | associated | |||
| PA27 | ADCY6 | Gene | Pathway | associated | |||
| PA28 | ADCY7 | Gene | Pathway | associated | |||
| PA29 | ADCY8 | Gene | Pathway | associated | |||
| PA29549 | HTR1B | Gene | Pathway | associated | 19741567 | ||
| PA29550 | HTR1D | Gene | Pathway | associated | 19741567 | ||
| PA29552 | HTR1E | Gene | Pathway | associated | 19741567 | ||
| PA29553 | HTR1F | Gene | Pathway | associated | 19741567 | ||
| PA30 | ADCY9 | Gene | Pathway | associated | |||
| PA34361 | RGS1 | Gene | Pathway | associated | |||
| PA39 | ADRB2 | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37923359 | 2024 | Integrins regulate hERG1 dynamics by girdin-dependent Gαi3: signaling and modeling in cancer cells. | 0 |
| 38636252 | 2024 | GNAI3 mediated by Lin28A regulates lipopolysaccharide-induced inflammation and osteogenic differentiation in periodontal stem cells by mediating the NF-κB/NLRP3 inflammasome pathway. | 1 |
| 37923359 | 2024 | Integrins regulate hERG1 dynamics by girdin-dependent Gαi3: signaling and modeling in cancer cells. | 0 |
| 38636252 | 2024 | GNAI3 mediated by Lin28A regulates lipopolysaccharide-induced inflammation and osteogenic differentiation in periodontal stem cells by mediating the NF-κB/NLRP3 inflammasome pathway. | 1 |
| 37153740 | 2023 | Gαi1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis. | 12 |
| 37153740 | 2023 | Gαi1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis. | 12 |
| 33723370 | 2021 | A novel missense variant of the GNAI3 gene and recognisable morphological characteristics of the mandibula in ARCND1. | 5 |
| 33723370 | 2021 | A novel missense variant of the GNAI3 gene and recognisable morphological characteristics of the mandibula in ARCND1. | 5 |
| 31386272 | 2020 | A highly conserved δ-opioid receptor region determines RGS4 interaction. | 2 |
| 32032744 | 2020 | Novel CpG-SNPs in the gastric acid secretion pathway GNAI3 and susceptibility to gastric cancer. | 5 |
| 31386272 | 2020 | A highly conserved δ-opioid receptor region determines RGS4 interaction. | 2 |
| 32032744 | 2020 | Novel CpG-SNPs in the gastric acid secretion pathway GNAI3 and susceptibility to gastric cancer. | 5 |
| 29472562 | 2018 | Gα(i)-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation. | 10 |
| 30279732 | 2018 | Gαi1 and Gαi3mediate VEGF-induced VEGFR2 endocytosis, signaling and angiogenesis. | 54 |
| 29472562 | 2018 | Gα(i)-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation. | 10 |
Citation
Dessen P
GNAI3 (G protein subunit alpha i3)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43277/gnai3-(g-protein-subunit-alpha-i3)
